zafirlukast

Known as: Cyclopentyl 3-(2-methoxy-4-((O-tolylsulfonyl)carbamoyl)benzyl)-1-methylindole-5-carbamate, Carbamic Acid,(3-((2-methoxy-4-((((2-methylphenyl)sulfonyl)amino)carbonyl)phenyl)methyl)-1-methyl-1H-indol-5-yl)-, Cyclopentyl Ester, 4-(5-cyclopentyloxycarbonylamino-2-methylindol-3-yl-methyl)-3-methoxy-N-O-tolylsulfonylbenzamide 
A toyl compound with anti-asthmatic property. Zafirlukast selectively and competitively binds and blocks the cysteinyl leukotriene 1 receptor… (More)
National Institutes of Health

Papers overview

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Highly Cited
2005
Highly Cited
2005
BACKGROUND Although guidelines recommend daily therapy for patients with mild persistent asthma, prescription patterns suggest… (More)
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Review
2002
Review
2002
Zafirlukast is a cysteinyl leukotriene type 1 receptor antagonist that causes bronchodilation and has anti-inflammatory… (More)
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Highly Cited
2002
Highly Cited
2002
Cough-variant asthma (CVA) occurs in a subgroup of asthmatics whose sole or predominant respiratory symptom is cough. Although… (More)
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Highly Cited
2000
Highly Cited
2000
Not all asthma can be adequately controlled, despite the use of high-dose inhaled corticosteroids. Because cysteinyl-leukotrienes… (More)
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2000
2000
BACKGROUND Few studies have compared the efficacy of inhaled corticosteroids and leukotriene modifiers for the treatment of… (More)
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Highly Cited
2000
Highly Cited
2000
Abnormality in the machinery of apoptosis is associated with a resistant phenotype of the tumor cell to chemotherapy. To… (More)
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Highly Cited
1999
Highly Cited
1999
The cysteinyl leukotrienes—leukotriene C4(LTC4), leukotriene D4(LTD4) and leukotriene E4(LTE 4)—are important mediators of human… (More)
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Highly Cited
1998
Highly Cited
1998
CONTEXT Zafirlukast is a potent leukotriene antagonist that recently was approved for the treatment of asthma. As use of this… (More)
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1998
1998
  • Calhoun
  • American journal of respiratory and critical care…
  • 1998
Zafirlukast is an orally active and selective cysteinyl leukotriene (cysLT) receptor antagonist. In humans, zafirlukast… (More)
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1997
1997
The efficacy of the oral leukotriene-receptor antagonist zafirlukast was assessed as maintenance therapy for patients with mild… (More)
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