Skip to search formSkip to main contentSkip to account menu

zafirlukast

Known as: Cyclopentyl 3-(2-methoxy-4-((O-tolylsulfonyl)carbamoyl)benzyl)-1-methylindole-5-carbamate, Carbamic Acid,(3-((2-methoxy-4-((((2-methylphenyl)sulfonyl)amino)carbonyl)phenyl)methyl)-1-methyl-1H-indol-5-yl)-, Cyclopentyl Ester, 4-(5-cyclopentyloxycarbonylamino-2-methylindol-3-yl-methyl)-3-methoxy-N-O-tolylsulfonylbenzamide 
A toyl compound with anti-asthmatic property. Zafirlukast selectively and competitively binds and blocks the cysteinyl leukotriene 1 receptor… 
National Institutes of Health

Related topics

Related topics

11 relations

Narrower (4)

AccolateAeronixICI-204,219Olmoran

Broader (3)

Anti-Asthmatic AgentsLeukotriene AntagonistsTosyl Compounds
AsthmaBronchodilation [PE]Drug Allergyzafirlukast 20 MG Oral Tablet [Accolate]

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2013
2013
Assessment of absorption potential of poorly water-soluble drugs by using the dissolution/permeation system.
Review
2011
Review
2011
Overview of the 2010 Food and Drug Administration Cardiovascular and Renal Drugs Advisory Committee Meeting Regarding Ticagrelor
Landmark clinical trials established the benefit of the thienopyridine clopidogrel, an irreversibly binding inhibitor of the… 
2006
2006
Pathological effects of glyoxalase I inhibition in SH‐SY5Y neuroblastoma cells
In Alzheimer's disease (AD), in aging, and under conditions of oxidative stress, the levels of reactive carbonyl compounds… 
2005
2005
Differential effect of zileuton, a 5-lipoxygenase inhibitor, against nociceptive paradigms in mice and rats
2003
2003
Treatment of acquired cold urticaria with cetirizine and zafirlukast in combination.
Acquired cold urticaria is an infrequent physical urticaria that can provoke severe systemic reactions. Histamine is the primary… 
Highly Cited
2002
Highly Cited
2002
Influence of zafirlukast and loratadine on exercise-induced bronchoconstriction.
BACKGROUND Airway obstruction induced by physical exercise is a common feature in asthma, and conventional treatments do not… 
2001
2001
5'-O-alkyl ethers of N,2-substituted adenosine derivatives: partial agonists for the adenosine A1 and A3 receptors.
New N,5'-di- and N,2,5'-trisubstituted adenosine derivatives were synthesized in good overall yields. Appropriate 5-O-alkyl… 
Highly Cited
2000
Highly Cited
2000
Effects of adding a leukotriene antagonist or a long-acting beta(2)-agonist in asthmatic patients with the glycine-16 beta(2)-adrenoceptor genotype.
Review
1998
Review
1998
New approaches to anti-inflammatory therapy for asthma.
1997
1997
The leukotriene receptor antagonist zafirlukast inhibits sulfur dioxide-induced bronchoconstriction in patients with asthma.
Inhalation of sulfur dioxide (SO2) causes bronchoconstriction in most people with asthma. To examine the role of leukotrienes in… 
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy (opens in a new tab), Terms of Service (opens in a new tab), and Dataset License (opens in a new tab)