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xestospongin C

Known as: XeC compound 
National Institutes of Health

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2 relations

Broader (2)

Macrocyclic CompoundsOxazoles

Papers overview

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2014
2014
Primary cultures of rat cortical microglia treated with nicotine increases in the expression of excitatory amino acid transporter 1 (GLAST) via the activation of the α7 nicotinic acetylcholine…
2008
2008
Calcium release via activation of presynaptic IP3 receptors contributes to kainate-induced IPSC facilitation in rat neocortex
2008
2008
Oscillatory membrane currents paradoxically induced via NO-activated pathways in detrusor cells.
2006
2006
Involvement of calcium-mediated apoptotic signals in H2O2-induced MIN6N8a cell death.
Highly Cited
2002
Highly Cited
2002
Xestospongin C, a novel blocker of IP3 receptor, attenuates the increase in cytosolic calcium level and degranulation that is induced by antigen in RBL‐2H3 mast cells
We evaluated the role of the cross‐linking of FcεRI‐mediated inositol 1,4,5‐triphosphate (IP3) in the increase in cytosolic Ca2… 
2001
2001
Modulation of early [Ca2+]i rise in metabolically inhibited endothelial cells by xestospongin C.
When energy metabolism is disrupted, endothelial cells lose Ca(2+) from endoplasmic reticulum (ER) and the cytosolic Ca(2… 
Highly Cited
2001
Highly Cited
2001
Brain‐derived neurotrophic factor triggers a rapid glutamate release through increase of intracellular Ca2+ and Na+ in cultured cerebellar neurons
We reported previously that BDNF induced glutamate release was dependent on intracellular Ca2+ but not extracellular Ca2+ in… 
Highly Cited
2001
Highly Cited
2001
Activation of inositol 1,4,5-trisphosphate receptor is essential for the opening of mouse TRP5 channels.
We studied the opening mechanism of Ca(2+)-permeable channels formed with mouse transient receptor potential type 5 (mTRP5) using… 
Highly Cited
2000
Highly Cited
2000
Xestospongin C, a selective and membrane‐permeable inhibitor of IP3 receptor, attenuates the positive inotropic effect of α‐adrenergic stimulation in guinea‐pig papillary muscle
We evaluated the role of the inositol 1,4,5‐triphosphate (IP3) receptor‐mediated Ca2+ release on the positive inotropic effects… 
2000
2000
A Xestospongin C-sensitive Ca2+ Store Is Required for cAMP-induced Ca2+ Influx and cAMP Oscillations inDictyostelium *
Xestospongin C (XeC) is known to bind to the inositol 1,4,5-trisphosphate (IP3)-sensitive store in mammalian cells and to inhibit… 
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