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TRPM2-mediated Ca2+ influx induces chemokine production in monocytes that aggravates inflammatory neutrophil infiltration
TLDR
It is shown that the plasma membrane Ca2+-permeable channel TRPM2 controls ROS-induced chemokine production in monocytes, which aggravates inflammation and is proposed as a new therapeutic strategy for treating inflammatory diseases. Expand
TRPA1 underlies a sensing mechanism for O2.
TLDR
A systematic evaluation of transient receptor potential (TRP) cation channels using reactive disulfides with different redox potentials reveals the capability of TRPA1 to sense O(2), and suggests a new O( 2)-sensing mechanism mediated by TRpa1. Expand
Reactive Oxygen Species Derived from NOX1/NADPH Oxidase Enhance Inflammatory Pain
TLDR
It is indicated that NOX1/NADPH oxidase accelerates the translocation of PKCε in DRG neurons, thereby enhancing the TRPV1 activity and the sensitivity to painful stimuli. Expand
A critical role of TRPM2 in neuronal cell death by hydrogen peroxide.
TLDR
The results suggest that TRPM2 plays a pivotal role in H2O2-induced neuronal death as redox-sensitive Ca2+-permeable channels expressed in neurons. Expand
Acute cold hypersensitivity characteristically induced by oxaliplatin is caused by the enhanced responsiveness of TRPA1 in mice
TLDR
It is suggested that a brief treatment with oxaliplatin or its metabolite oxalate is sufficient to enhance the responsiveness of TRPA1 but not that of TRPM8 and TRPV1 expressed by DRG neurons, which may contribute to the characteristic acute peripheral neuropathy induced by oxali Platin. Expand
Nicotinic Acetylcholine Receptor-Mediated Neuroprotection by Donepezil Against Glutamate Neurotoxicity in Rat Cortical Neurons
TLDR
The results suggest that donepezil not only protects cortical neurons against glutamate neurotoxicity via α4β2- and α7-nAChRs but also prevents apoptotic neuronal death. Expand
TRPM2 Contributes to Inflammatory and Neuropathic Pain through the Aggravation of Pronociceptive Inflammatory Responses in Mice
TLDR
The results of the present study suggest that TRPM2 expressed in macrophages and microglia aggravates peripheral and spinal pronociceptive inflammatory responses and contributes to the pathogenesis of inflammatory and neuropathic pain. Expand
TRPV1 stimulation triggers apoptotic cell death of rat cortical neurons.
TLDR
Together, these data indicate that TRPV1 activation triggers apoptotic cell death of rat cortical cultures via L-type Ca(2+) channel opening, Ca( 2+) influx, ERK phosphorylation, and reactive oxygen species production. Expand
Raphe AMPA receptors and nicotinic acetylcholine receptors mediate ketamine-induced serotonin release in the rat prefrontal cortex.
TLDR
Results suggest that AMPARs and α 4 β 2-nAChRs in the DRN play a key role in the ketamine-induced 5-HT release in the prefrontal cortex. Expand
Cloning and expression of a cDNA for the rat kappa-opioid receptor.
TLDR
Northern blot analysis demonstrated that kappa-opioid receptor mRNA is expressed in a regionally specific manner in rat brain. Expand
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