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The Transient Receptor Potential Protein Homologue TRP6 Is the Essential Component of Vascular &agr;1-Adrenoceptor–Activated Ca2+-Permeable Cation Channel
TLDR
It is found that heterologous expression of murine TRP6 in HEK293 cells reproduces almost exactly the essential biophysical and pharmacological properties of &agr;1-adrenoceptor–activated nonselective cation channels (&agr–1-AR–NSCC) previously identified in rabbit portal vein smooth muscle.
Nitric oxide activates TRP channels by cysteine S-nitrosylation
TLDR
Findings reveal the structural motif for the NO-sensitive activation gate in TRP channels and indicate that NO sensors are a new functional category of cellular receptors extending over different TRP families.
Rings of negatively charged amino acids determine the acetylcholine receptor channel conductance
TLDR
The single-channel conductance properties of these AChR mutants expressed in Xenopus laevis oocytes indicate that three clusters of negatively charged and glutamine residues neighbouring segment M2 of the α-, β-, γ- and δ-subunits, probably forming three anionic rings, are major determinants of the rate of ion transport.
TRPM2-mediated Ca2+ influx induces chemokine production in monocytes that aggravates inflammatory neutrophil infiltration
TLDR
It is shown that the plasma membrane Ca2+-permeable channel TRPM2 controls ROS-induced chemokine production in monocytes, which aggravates inflammation and is proposed as a new therapeutic strategy for treating inflammatory diseases.
Selective and direct inhibition of TRPC3 channels underlies biological activities of a pyrazole compound
TLDR
TheTRPC3-selective inhibitor Pyr3 is a powerful tool to study in vivo function of TRPC3, suggesting a pharmaceutical potential of Pyr3 in treatments of TR PC3-related diseases such as cardiac hypertrophy.
Molecular and Functional Characterization of a Novel Mouse Transient Receptor Potential Protein Homologue TRP7
TLDR
These findings reveal an interesting correspondence of TRP7 to the background and receptor stimulation-induced cation currents in various native systems and suggest that the TRP6 channel is a new member of diacylglycerol-activated cation channels.
Calcium channel β-subunit binds to a conserved motif in the I–II cytoplasmic linker of the α1-subunit
TLDR
It is reported that the β-subunit binds to the cytoplasmic linker between repeats I and II of the dihydropyridine-sensitive α 1-sub units from skeletal and cardiac muscles, and also with the more distantly related neuronal α 1A and ω-conotoxin GVIA-sensitive aα 1B-subunits.
TRPM1 is a component of the retinal ON bipolar cell transduction channel in the mGluR6 cascade
TLDR
It is demonstrated that TRPM1-L is a component of the ON BC transduction channel downstream of mGluR6 in ON BCs, and functions as a constitutively active nonselective cation channel and its activity is negatively regulated by Go in the mGLUR6 cascade.
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