Primary cultures of rat cortical microglia treated with nicotine increases in the expression of excitatory amino acid transporter 1 (GLAST) via the activation of the α7 nicotinic acetylcholine receptor.

@article{Morioka2014PrimaryCO,
  title={Primary cultures of rat cortical microglia treated with nicotine increases in the expression of excitatory amino acid transporter 1 (GLAST) via the activation of the α7 nicotinic acetylcholine receptor.},
  author={Norimitsu Morioka and Masato Tokuhara and Yoki Nakamura and Yuko Idenoshita and Sakura Harano and Fang Fang Zhang and Kazue Hisaoka-Nakashima and Yoshihiro Nakata},
  journal={Neuroscience},
  year={2014},
  volume={258},
  pages={374-84}
}
Although the clearance of glutamate from the synapse under physiological conditions is performed by astrocytic glutamate transporters, their expression might be diminished under pathological conditions. Microglia glutamate transporters, however, might serve as a back-up system when astrocytic glutamate uptake is impaired, and could have a prominent neuroprotective function under pathological conditions. In the current study, the effect of nicotine, well known as a neuroprotective molecule, on… CONTINUE READING

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