wybutosine
National Institutes of Health
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Background: 4-Demethylwyosine synthase (TYW1) is a tRNA-modifying metalloenzyme involved in the biosynthesis of wyosine. Results…
TYW1 catalyzes the condensation of N-methylguanosine with two carbon atoms from an unknown second substrate to form 4…
Wyosine (imG) and its derivatives such as wybutosine (yW) are found at position 37 of phenylalanine-specific transfer RNA (tRNA…
Wybutosine (yW), one of the most complicated modified nucleosides, is found in the anticodon loop of eukaryotic phenylalanine…
Wye bases are tricyclic bases that are found in archaeal and eukaryotic tRNAs. The most modified wye base, wybutosine, which…
An improved synthesis of 3-beta-D-ribofuranosylwybutine (2) has been achieved by the Wittig reaction between 4,6-dimethyl-9-oxo-3…
Yeast tRNA Phe, enriched in carbon-13 specifically at the naturally occurring methyl groups, has been produced through…