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Redox status of plasma coenzyme Q10 indicates elevated systemic oxidative stress in Parkinson's disease
TLDR
A slight but significant elevation in %CoQ-10 was observed in PD patients when compared with age/gender-matched normal subjects, suggesting elevated systemic oxidative stress inPD patients. Expand
Role of natural killer cells and TCRγ δ T cells in acute autoimmune encephalomyelitis
TLDR
It is suggested that NK cells play a suppressive role in acute EAE whereas TCRγ δ + T cells are not involved in the development of or recovery from the disease. Expand
The role of matrix metalloproteinase-9 in cigarette smoke-induced emphysema.
TLDR
Results suggest that M MP-9 in humans who smoke is similar to smoke-exposed mice, where MMP-9 is present in emphysematous lung but not correlated with theEmphysema, and specific inhibition of MMP -9 is unlikely to be an effective therapy for cigarette smoke-induced emphySEma. Expand
An increase of oxidized coenzyme Q-10 occurs in the plasma of sporadic ALS patients
TLDR
Comparison of plasma redox status of coenzyme Q-10 in sporadic amyotrophic lateral sclerosis patients with those in healthy age/sex-matched controls suggests systemic oxidative stress in the pathogenesis of sALS. Expand
DNA polymerase γ inhibition by vitamin K3 induces mitochondria‐mediated cytotoxicity in human cancer cells
TLDR
It is demonstrated that VK3 selectively inhibits DNA polymerase (pol) γ, the key enzyme responsible for mitochondrial DNA replication and repair, and that this compound seems to exert its anticancer activity by two possible mechanisms in a concentration‐dependent manner. Expand
Diazoxide potentiates mesenchymal stem cell survival via NF-kappaB-dependent miR-146a expression by targeting Fas.
TLDR
It is demonstrated that cytoprotection afforded by preconditioning of MSCs with DZ was regulated by miR-146a induction, which may be a novel therapeutic target in cardiac ischemic diseases. Expand
Immunohistochemical Staining Methods for Connexin32 on Formalin-Fixed Paraffin-Embedded Sections
TLDR
The CSA method is considered an appropriate method for the detection of Cx32 in formalin-fixed paraffin-embedded sections and a decrease in the signals was shown in the liver of rats treated with phenobarbital or in hepatocellular adenoma, which were consistent with previous reports using cryosections. Expand
Identification of Antioxidants Produced by Lactobacillus plantarum
TLDR
Spectroscopic analyses proved two compounds that demonstrated 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging activity from cultures of Lactobacillus plantarum to be L-3-(4-hydroxyphenyl) lactic acid and L-indole-3-lactic acid. Expand
Interaction between apoptotic cells and reactive brain cells in the central nervous system of rats with autoimmune encephalomyelitis
TLDR
The present study suggests that astrocytes, rather than microglia, induce programmed cell death of infiltrating inflammatory cells, which may be one mechanism by which T cells are eliminated from the CNS. Expand
Crystal structure of the radical SAM enzyme catalyzing tricyclic modified base formation in tRNA.
TLDR
Mutational analyses in yeast supported the validity of this complex model structure, which provides a structural insight into the radical reaction involving two [4Fe-4S] clusters to create a complex tricyclic base. Expand
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