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vesnarinone

Known as: 3,4-dihydro-6-(4-(3,4-dimethoxybenzoyl)-1-piperazinyl)-2-1H-quinolinone, vesnarinone [Chemical/Ingredient], 3,4-Dihydro-6-(4-(3,4-dimethoxybenzoyl)-1-pip- erazinyl)- 2(1H)-quinolinone 
A cardiotonic quinolinone derivative, that suppresses cell proliferation and induces apoptosis by inducing the expression of p21, an inhibitor of… 
National Institutes of Health

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9 relations

Broader (6)

Antineoplastic AgentsAntiviral AgentsCardiotonic AgentsImmunologic Adjuvants

Narrower (3)

ArkinArkin-ZOPC 8212

Papers overview

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Review
2003
Review
2003
Role of nonglycosidic inotropic agents: indications, ethics, and limitations.
Review
2000
Review
2000
New drugs in the treatment of heart failure.
1995
1995
Alterations of the cytoskeletal organization in tumor cell lines by a cardiotonic drug, vesnarinone, through protein tyrosine phosphorylation.
We describe nonspecific and moderate activation of cellular protein tyrosine phosphorylation by a chemical compound, vesnarinone… 
1995
1995
Antagonizing effects of a novel antipsychotic quinolinone derivative (OPC-14597) on dopaminergic inhibition of neuronal activities in the nucleus accumbens
1994
1994
Effects of a Novel Cardiotonic Agent (±)-6-[3-(3,4‐Dimethoxybenzylamino)-2‐Hydroxypropoxy]-2(1H)-Quinolinone (OPC‐18790) on Contractile Force, Cyclic AMP Level, and Aequorin Light Transients in Dog…
Summary: We studied the effects of a novel cardiotonic agent OPC-18790 [(±)-6-[3-(3,4-dimethoxybenzylamino)-2-hydroxypropoxy]-2… 
Review
1994
Review
1994
Nonglycoside inotropes in congestive heart failure. Are they beneficial or harmful?
1993
1993
Vesnarinone inhibits production of HIV-1 in cultured cells.
Vesnarinone, a synthetic oral cardiotonic agent that has been used for treatment of patients with congestive heart failure, was… 
1993
1993
Two isoforms of cGMP-inhibited cyclic nucleotide phosphodiesterases in human tissues distinguished by their responses to vesnarinone, a new cardiotonic agent.
We examined the inhibitory effects of vesnarinone, a new cardiotonic agent, on human cyclic nucleotide phosphodiesterase (PDE… 
1992
1992
Effects of a Nonpeptide Vasopressin Antagonist (OPC‐21268) on Cytosolic Ca2+ Concentration in Vascular and Cardiac Myocytes
A selective V, antagonist, l-{l-[4(3-acetylaminopropoxy)benzoyl]-4-piperidyl}-3,4-dihydro-2(1H)-quinolinone (OPC-21268), which is… 
1991
1991
Effect of a new V1 antagonist (OPC-21268) on vascular action of vasopressin in cultured rat vascular smooth muscle cells.
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