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Bioactive macrolides and polyketides from marine dinoflagellates of the genus Amphidinium.
This review covers the results described in recent publications on a series of cytotoxic macrolides, designated amphidinolides, and long-chain polyketides isolated from Amphidinium spp. Expand
Zamamidine C, 3,4-dihydro-6-hydroxy-10,11-epoxymanzamine A, and 3,4-dihydromanzamine J N-oxide, new manzamine alkaloids from sponge Amphimedon sp.
Abstract New manzamine alkaloids, zamamidine C ( 1 ), 3,4-dihydro-6-hydroxy-10,11-epoxymanzamine A ( 2 ), and 3,4-dihydromanzamine J N -oxide ( 3 ), have been isolated from an Okinawan marine spongeExpand
Cloning of polyketide synthase genes from amphidinolide-producing dinoflagellate Amphidinium sp.
The deduced gene products in the positive clone showed similarity with beta-ketoacyl synthase (KS), acyl transferase (AT), dehydratase (DH), ketoreductase (KR), and acyl carrier protein (ACP) in known type I PKSs and thioesterase (TE). Expand
Halichonadins K and L, new dimeric sesquiterpenoids from a sponge Halichondria sp.
Two new structurally unique dimeric sesquiterpenoids, halichonadins K (1) and L (2), were isolated from an Okinawan marine sponge Halichondria sp. The structures of 1 and 2 were elucidated on theExpand
Biosynthesis of ε-poly-l-lysine in a cell-free system of Streptomyces albulus
Abstract e-Poly- l -lysine (e-PL) is a homo-poly-amino acid characterized by a peptide bond between carboxyl and e-amino groups of l -lysine. Here we report the cell-free synthesis of e-PL by aExpand
Biosynthesis of epsilon-poly-L-lysine in a cell-free system of Streptomyces albulus.
The results suggest that the biosynthesis of epsilon-PL is nonribosomal peptide synthesis and is catalyzed by membrane bound enzyme(s) rather than ribonuclease, kanamycin, or chloramphenicol. Expand
Brasilicardin A, a natural immunosuppressant, targets amino Acid transport system L.
The results suggest that the immunosuppressive activity of BraA is induced by amino acid deprivation via the inhibition of system L and that the amino acid transporter is a target for Immunosuppressant. Expand
Lycopladines B-D and lyconadin B, new alkaloids from Lycopodium complanatum.
Four new alkaloids, lycopladines B-D (1-3) and lyconadin B (4), have been isolated from the club moss Lycopodium complanatum and the structures including the stereochemistry were elucidated on theExpand
Sedimentibacter acidaminivorans sp. nov., an anaerobic, amino-acid-utilizing bacterium isolated from marine subsurface sediment.
A novel, anaerobic bacterium isolated from a methanogenic microbial community, which was originally obtained from marine subsurface sediments collected from off the Shimokita Peninsula of Japan, is considered to represent a novel species of the genus Sedimentibacter. Expand
Pyrinodemins B-D, potent cytotoxic bis-pyridine alkaloids from marine sponge amphimedon sp.
New bis-pyridine alkaloids, pyrinodemins B-D (1-3), have been isolated together with pyrinodemin A (4) and related 3-alkyl pyridine alkaloids 5-8 from the Okinawan marine sponge Amphimedon sp. andExpand