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Ceramide is involved in triggering of cardiomyocyte apoptosis induced by ischemia and reperfusion.
Involvement of ceramide signaling in the initiation of apoptosis induction in myocardial cells by in vitro and in vivo ischemia and reperfusion was analyzed. Synthetic cell permeable C2-ceramideExpand
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Ischemic preconditioning decreases apoptosis in rat hearts in vivo.
BACKGROUND Previous studies have demonstrated that ischemic preconditioning prevents lethal cell injury and, as a consequence, limits infarct size in rat heart. Although both apoptosis and necrosisExpand
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Determination of buffering capacity of rat myocardium during ischemia.
To determine the buffering capacity of ischemic rat myocardium, lactate production was altered by glycogen depletion prior to total global ischemia. Lactate production was monitored by 1H-NMRExpand
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Improved hemodynamic function and mechanical efficiency in congestive heart failure with sodium dichloroacetate.
OBJECTIVES The purpose of this study was to determine whether sodium dichloroacetate improves hemodynamic performance and mechanical efficiency in congestive heart failure. BACKGROUND CongestiveExpand
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Exposure to environmental tobacco smoke increases myocardial infarct size in rats.
BACKGROUND Exposure to environmental tobacco smoke (ETS) has been epidemiologically linked to death from ischemic heart disease in nonsmokers. In this study, we evaluated the influence of 3 days, 3Expand
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Heat-shock protein induction in rat hearts. A direct correlation between the amount of heat-shock protein induced and the degree of myocardial protection.
BACKGROUND Previous studies have demonstrated that heat-shock treatment results in the induction of 72-kD heat-shock protein (HSP72) and a reduction of infarct size after subsequent ischemia andExpand
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Heat Shock Protein Induction in Rat Hearts: A Role for Improved Myocardial Salvage After Ischemia and Reperfusion?
BackgroundTo test the hypothesis that the heat shock response is associated with improved myocardial salvage after myocardial ischemia and reperfusion, rats treated with prior whole-body hyperthermiaExpand
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Noninvasive evaluation of pulmonary artery pressure during exercise by saline-enhanced Doppler echocardiography in chronic pulmonary disease.
To determine the feasibility of noninvasive determination of right ventricular systolic pressure (RVSP) during a graded-exercise protocol, saline contrast-enhanced Doppler echocardiography ofExpand
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Loss of Myocardial Protection After Preconditioning Correlates With the Time Course of Glycogen Recovery Within the Preconditioned Segment
BackgroundAlthough previous investigators have demonstrated that myocardial preconditioning reduces infarct size, the mechanisms of cardioprotection associated with preconditioning are not completelyExpand
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Overexpression of heat shock protein 72 in transgenic mice decreases infarct size in vivo.
BACKGROUND Previous studies have demonstrated that induction of heat shock protein (HSP) 72 by whole-body hyperthermia reduces infarct size in an in vivo model of ischemia and reperfusion.Expand
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