trypanothione synthetase

Known as: trypanothione synthase 
 
National Institutes of Health

Topic mentions per year

Topic mentions per year

2003-2016
012320032016

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2016
2016
BACKGROUND The search for novel chemical entities targeting essential and parasite-specific pathways is considered a priority for… (More)
  • figure 1
  • table 1
  • figure 2
  • figure 3
  • table 2
Is this relevant?
2014
2014
Kinetoplastids differ from other organisms in their ability to conjugate glutathione and spermidine to form trypanothione which… (More)
  • figure 2
  • figure 3
  • figure 5
  • figure 6
  • figure 7
Is this relevant?
2014
2014
Trypanothione is a unique and essential redox metabolite of trypanosomatid parasites, the biosynthetic pathway of which is… (More)
Is this relevant?
2013
2013
In pathogenic trypanosomes, trypanothione synthetase (TryS) catalyzes the synthesis of both glutathionylspermidine (Gsp) and… (More)
Is this relevant?
2013
2013
The trypanothione synthetase (TryS) catalyses the two-step biosynthesis of trypanothione from spermidine and glutathione and is… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
2012
2012
Trypanothione synthetase (TryS) is essential for the survival of the protozoan parasite Trypanosoma brucei, which causes human… (More)
  • table 1
  • table 2
  • table 4
  • table 3
  • table 5
Is this relevant?
2009
2009
In the search for new therapeutics for the treatment of human African trypanosomiasis, many potential drug targets in Trypanosoma… (More)
Is this relevant?
2008
2008
Trypanothione synthetase (TryS) is an important enzyme for survival of Leishmania; thus an important target for structure based… (More)
  • figure 1
  • figure 3
  • figure 2
Is this relevant?
2005
2005
In Crithidia fasciculata the biosynthesis of trypanothione (N(1),N(8)-bis(glutathionyl)spermidine; reduced trypanothione), a… (More)
Is this relevant?
2003
2003
Trypanothione [T(SH)2], the major redox mediator in pathogenic trypanosomatids, is synthetized stepwise by two distinct enzymes… (More)
Is this relevant?