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trypanothione synthetase

Known as: trypanothione synthase 
National Institutes of Health

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2 relations

Broader (2)

Amide SynthasesLigase

Papers overview

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2019
2019
In silico and in vitro comparative activity of green tea components against Leishmania infantum.
2019
2019
Mitochondrial disfunction and ROS production are essential for anti‐Trypanosoma cruzi activity of &bgr;‐lapachone‐derived naphthoimidazoles
Review
2016
Review
2016
Thiol redox biology of trypanosomatids and potential targets for chemotherapy.
2013
2013
Molecular mechanism underlying antileishmanial effect of oxabicyclo[3.3.1]nonanones: inhibition of key redox enzymes of the pathogen.
2013
2013
Molecular Dynamics Reveal Binding Mode of Glutathionylspermidine by Trypanothione Synthetase
The trypanothione synthetase (TryS) catalyses the two-step biosynthesis of trypanothione from spermidine and glutathione and is… 
Review
2011
Review
2011
Polyamine metabolism in Leishmania: from arginine to trypanothione
Polyamines (PAs) are essential metabolites in eukaryotes, participating in a variety of proliferative processes, and in… 
2009
2009
Trypanothione reductase from Leishmania infantum: cloning, expression, purification, crystallization and preliminary X-ray data analysis.
The most promising targets for Leishmania-specific drug design are two key enzymes involved in the unique thiol-based metabolism… 
2006
2006
Design, synthesis, and biological evaluation of phosphinopeptides against Trypanosoma cruzi targeting trypanothione biosynthesis.
As a part of our project aimed at the search for new safe chemotherapeutic and chemoprophylactic agents against American… 
2003
2003
Biosynthesis of Trypanothione in Trypanosoma brucei brucei
Abstract Trypanothione [T(SH)2], the major redox mediator in pathogenic trypanosomatids, is synthetized stepwise by two distinct… 
1990
1990
Biosynthesis of the trypanosomatid metabolite trypanothione: purification and characterization of trypanothione synthetase from Crithidia fasciculata.
Trypanothione synthetase from Crithidia fasciculata has been purified ca. 14,500-fold to homogeneity in an overall yield of 40… 
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