Ligase

Known as: EC 6, Ligases, Synthetases 
Major class of enzymes that catalyze the linking together of two molecules (EC class 6) for example DNA ligases that link two fragments of DNA by… (More)

Topic mentions per year

Topic mentions per year

1950-2017
010002000300019502016

Papers overview

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Highly Cited
2011
Highly Cited
2011
Since the publication of the American Association for the Study of Liver Diseases (AASLD) practice guidelines on the management… (More)
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Highly Cited
2007
Highly Cited
2007
Retinoic-acid-inducible gene-I (RIG-I; also called DDX58) is a cytosolic viral RNA receptor that interacts with MAVS (also called… (More)
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Highly Cited
2004
Highly Cited
2004
Skeletal muscle atrophy is a debilitating response to fasting, disuse, cancer, and other systemic diseases. In atrophying muscles… (More)
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Highly Cited
2004
Highly Cited
2004
NF-kappaB transcription factors mediate the effects of pro-inflammatory cytokines such as tumour necrosis factor-alpha and… (More)
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Highly Cited
2004
Highly Cited
2004
Transcription factor Nrf2 is a major regulator of genes encoding phase 2 detoxifying enzymes and antioxidant stress proteins in… (More)
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Highly Cited
2004
Highly Cited
2004
Skeletal muscle size depends upon a dynamic balance between anabolic (or hypertrophic) and catabolic (or atrophic) processes… (More)
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Highly Cited
2001
Highly Cited
2001
Skeletal muscle adapts to decreases in activity and load by undergoing atrophy. To identify candidate molecular mediators of… (More)
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Highly Cited
2000
Highly Cited
2000
Autosomal recessive juvenile parkinsonism (AR–JP), one of the most common familial forms of Parkinson disease, is characterized… (More)
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Highly Cited
1997
Highly Cited
1997
The tumor suppressor p53 is degraded by the ubiquitin-proteasome system. p53 was polyubiquitinated in the presence of E1, UbcH5… (More)
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Highly Cited
1993
Highly Cited
1993
The ubiquitin-dependent proteolytic pathway plays a major role in selective protein degradation. Ubiquitination of proteins… (More)
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