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Ligase

Known as: EC 6, Ligases, Synthetases 
Major class of enzymes that catalyze the linking together of two molecules (EC class 6) for example DNA ligases that link two fragments of DNA by… 
National Institutes of Health

Related topics

Related topics

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Narrower (33)

2,3-dihydroxybenzoate-AMP ligase, E coli4-methyleneglutamine synthetase5-Formyltetrahydrofolate cyclo-ligase6-methylsalicylic acid synthetase
Coenzyme ADNA LigasesEnzyme GeneGlutamate-Cysteine Ligase

Broader (1)

Enzymes

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2011
Highly Cited
2011
PINK1 and Parkin Target Miro for Phosphorylation and Degradation to Arrest Mitochondrial Motility
Highly Cited
2005
Highly Cited
2005
Targeting quantum dots to surface proteins in living cells with biotin ligase.
Escherichia coli biotin ligase site-specifically biotinylates a lysine side chain within a 15-amino acid acceptor peptide (AP… 
Highly Cited
2004
Highly Cited
2004
The ubiquitin ligase COP1 is a critical negative regulator of p53
COP1 (constitutively photomorphogenic 1) is a RING-finger-containing protein that functions to repress plant photomorphogenesis… 
Highly Cited
2002
Highly Cited
2002
The SCF(COI1) ubiquitin-ligase complexes are required for jasmonate response in Arabidopsis.
Xie and colleagues previously isolated the Arabidopsis COI1 gene that is required for response to jasmonates (JAs), which… 
Highly Cited
2002
Highly Cited
2002
E3 ubiquitin ligase that recognizes sugar chains
N-glycosylation of proteins in the endoplasmic reticulum (ER) has a central role in protein quality control. Here we report that… 
Highly Cited
2000
Highly Cited
2000
Ku Recruits the XRCC4-Ligase IV Complex to DNA Ends
ABSTRACT Genetic experiments have determined that Ku, XRCC4, and ligase IV are required for repair of double-strand breaks by the… 
Highly Cited
1999
Highly Cited
1999
Rbx1, a component of the VHL tumor suppressor complex and SCF ubiquitin ligase.
The von Hippel-Lindau (VHL) tumor suppressor gene is mutated in most human kidney cancers. The VHL protein is part of a complex… 
Highly Cited
1995
Highly Cited
1995
Detection of glycopeptide resistance genotypes and identification to the species level of clinically relevant enterococci by PCR
Highly Cited
1990
Highly Cited
1990
Release of endothelin from the porcine aorta. Inhibition by endothelium-derived nitric oxide.
This study was designed to examine whether endothelin is released from the intima of intact arteries, and whether endothelium… 
Highly Cited
1988
Highly Cited
1988
A ligase-mediated gene detection technique.
An assay for the presence of given DNA sequences has been developed, based on the ability of two oligonucleotides to anneal… 
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