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5-Formyltetrahydrofolate cyclo-ligase

Known as: 5,10-methenyltetrahydrofolate synthetase, 5,10-MTHF synthetase, 5-formyl tetrahydrofolate cyclodehydrase 
 
National Institutes of Health

Related topics

Related topics

4 relations
5-formyltetrahydrofolate cyclo-ligase activityMTHFS gene

Broader (2)

Carbon-Nitrogen LigasesLigase

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2011
2011
A 5-formyltetrahydrofolate cycloligase paralog from all domains of life: comparative genomic and experimental evidence for a cryptic role in thiamin metabolism
A paralog (here termed COG0212) of the ATP-dependent folate salvage enzyme 5-formyltetrahydrofolate cycloligase (5-FCL) occurs in… Expand
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2011
2011
Transcriptome mining of active biosynthetic pathways and their associated products in Streptomyces flaveolus.
Natural products (NPs) are small molecules of incredible structural diversity that have long been appreciated for their critical… Expand
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2009
2009
Structural basis for the inhibition of human 5,10-methenyltetrahydrofolate synthetase by N10-substituted folate analogues.
5,10-Methenyltetrahydrofolate synthetase (MTHFS) regulates the flow of carbon through the one-carbon metabolic network, which… Expand
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2007
2007
Inhibition of 5,10-methenyltetrahydrofolate synthetase.
The interaction of 5-formyltetrahydrofolate analogs with murine methenyltetrahydrofolate synthetase (MTHFS) was investigated… Expand
2004
2004
Cloning, expression, and purification of 5,10-methenyltetrahydrofolate synthetase from Mus musculus.
Folate metabolism is necessary for the biosyntheses of purine nucleotides and thymidylate and for the synthesis of S… Expand
2002
2002
Cloning and Characterization of Mitochondrial 5-Formyltetrahydrofolate Cycloligase from Higher Plants*
5-Formyltetrahydrofolate cycloligase (5-FCL) catalyzes the conversion of 5-formyltetrahydrofolate (5-CHO-H4PteGlun) to 5,10… Expand
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1994
1994
Primary structure and tetrahydropteroylglutamate binding site of rabbit liver cytosolic 5,10-methenyltetrahydrofolate synthetase.
The primary sequence of 5,10-methenyltetrahydrofolate synthetase from rabbit liver was determined by amino acid sequencing of the… Expand
Highly Cited
1991
Highly Cited
1991
5-Formyltetrahydrofolate polyglutamates are slow tight binding inhibitors of serine hydroxymethyltransferase.
The interaction of the mono- and triglutamate forms of 5-methyltetrahydrofolate and 5-formyltetrahydrofolate with serine… Expand
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1991
1991
Effect of nitrous oxide and methotrexate on folate coenzyme pools of blast cells from leukemia patients.
The effects of methotrexate (inhibiting dihydrofolate reductase) and nitrous oxide (inactivating methionine synthase) on… Expand
1984
1984
Purification and properties of 5,10-methenyltetrahydrofolate synthetase from Lactobacillus casei.
5,10-Methenyltetrahydrofolate synthetase (EC 6.3.3.2), which catalyzes the ATP- and Mg2+ -dependent isomerization of 5-formyl- to… Expand
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