• Publications
  • Influence
Metabolism of N-acetylbenzidine and initiation of bladder cancer.
TLDR
Results suggest BZ initiation of bladder cancer is complex, involving multiple organs and metabolic pathways and N-acetylation, N-glucuronidation, peroxidation, and RNOS, which offer a new pathway for metabolism and potential activation. Expand
Glucuronide conjugates of 4-aminobiphenyl and its N-hydroxy metabolites. pH stability and synthesis by human and dog liver.
TLDR
The glucuronide of 4-aminobiphenyl is a major product of dog and human liver slice metabolism and likely to play an important role in the carcinogenic process. Expand
Human N-acetylation of benzidine: role of NAT1 and NAT2.
TLDR
A combination of human recombinant NAT and liver slice experiments has demonstrated that benzidine and N-acetylbenzidine are both preferred substrates for NAT1, and suggests that NAT1 may exhibit a polymorphic expression in human liver. Expand
Glucuronidation of benzidine and its metabolites by cDNA-expressed human UDP-glucuronosyltransferases and pH stability of glucuronides.
TLDR
The relative pH stability of O-glucuronides is consistent with a role in detoxification and excretion of aromatic amine-induced bladder cancer, while the acid lability of N-glUCuronides are consistent with delivery of these amines to the bladder epithelium for activation, resulting in DNA adducts which may lead to mutations. Expand
N-glucuronidation of benzidine and its metabolites. Role in bladder cancer.
TLDR
Results suggest multiple pathways (acetylation, glucuronidation, peroxidation) in multiple organs (liver, blood, kidney, bladder) are important in benzidine-induced bladder cancer. Expand
Separation of cyclic 3',5'-nucleoside monophosphates from other nucleotides on aluminum oxide columns. Application to the assay of adenyl cyclase and guanyl cyclase.
TLDR
A method is described for separating 3′,5′-nucleoside monophosphates from other nucleotides on columns of aluminum oxide and an α-32P-labeled nucleoside triphosphate provides a specific precursor for use in assaying cyclase enzymes. Expand
A protein from polymorphonuclear leukocytes (LEM) which affects the rate of hepatic amino acid transport and synthesis of acute-phase globulins.
TLDR
The effects of LEM in stimulating hepatic amino acid transport appear to be direct, without mediation by other hormones, and to be independent of cAMP. Expand
DNA adducts formed by ring-oxidation of the carcinogen 2-naphthylamine with prostaglandin H synthase in vitro and in the dog urothelium in vivo.
TLDR
Results suggest that a minor proportion of the DNA adducts found in vivo may be formed by PHS-activation of 2-NA in the target tissue, and ring-oxidation products of arylamines and of other carcinogenic aryl compounds should be evaluated as proximate carcinogenic metabolites. Expand
Effect of age on the conversion of 25-hydroxyvitamin D3 to 1,25-dihydroxyvitamin D3 by kidney of rat.
TLDR
There is a marked decrease in the capacity of the vitamin D-deficient adult rat to convert 25-hydroxyvitamin D3 to 1,25-dihydroxyv vitamin D3, the physiologically active form of vitamin D. Expand
DDAVP (1-desamino-8-D-arginine-vasopressin) treatment of central diabetes insipidus--mechanism of prolonged antidiuresis.
TLDR
The prolonged antidiuresis of intranasally administered DDAVP is due to slow absorption, presistence in plasma, and enchanced effect on the kidney. Expand
...
1
2
3
4
5
...