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- Publications
- Influence
Redox control in trypanosomatids, parasitic protozoa with trypanothione-based thiol metabolism.
- R. L. Krauth-Siegel, M. Comini
- Chemistry, Medicine
- Biochimica et biophysica acta
- 1 November 2008
Trypanosomes and leishmania, the causative agents of several tropical diseases, possess a unique redox metabolism which is based on trypanothione. The bis(glutathionyl)spermidine is the central thiol… Expand
Validation of Trypanosoma brucei trypanothione synthetase as drug target.
- M. Comini, S. Guerrero, Simon Haile, U. Menge, H. Lünsdorf, L. Flohé
- Biology, Medicine
- Free radical biology & medicine
- 15 May 2004
In trypanosomes, the parasite-specific thiol trypanothione [T(SH)2] fulfills various functions, the best established being detoxification of H2O2 and organic hydroperoxides and ribonucleotide… Expand
Identification of novel bacterial plasminogen‐binding proteins in the human pathogen Mycobacterium tuberculosis
- W. Xolalpa, Antonio J Vallecillo, +5 authors C. Espitia
- Biology, Medicine
- Proteomics
- 1 September 2007
Binding and activation of human plasminogen (Plg) to generate the proteolytic enzyme plasmin (Plm) have been associated with the invasive potential of certain bacteria. In this work, proteomic… Expand
Trypanothione Synthesis in Crithidia Revisited*
- M. Comini, U. Menge, J. Wissing, L. Flohé
- Biology, Medicine
- Journal of Biological Chemistry
- 25 February 2005
In Crithidia fasciculata the biosynthesis of trypanothione (N1,N8-bis(glutathionyl)spermidine; reduced trypanothione), a redox mediator unique to and essential for pathogenic trypanosomatids, was… Expand
Insights into the redox biology of Trypanosoma cruzi: Trypanothione metabolism and oxidant detoxification.
- F. Irigoín, Lucía Cibils, M. Comini, S. Wilkinson, L. Flohé, R. Radi
- Biology, Medicine
- Free radical biology & medicine
- 15 September 2008
Trypanosoma cruzi is the etiologic agent of Chagas' disease, an infection that affects several million people in Latin America. With no immediate prospect of a vaccine and problems associated with… Expand
Catalytic mechanism of the glutathione peroxidase-type tryparedoxin peroxidase of Trypanosoma brucei.
- Tanja Schlecker, M. Comini, J. Melchers, T. Ruppert, R. L. Krauth-Siegel
- Chemistry, Medicine
- The Biochemical journal
- 1 August 2007
Trypanosoma brucei, the causative agent of African sleeping sickness, encodes three nearly identical genes for cysteine-homologues of the selenocysteine-containing glutathione peroxidases. The… Expand
Evaluation of the diagnostic value of measuring IgG, IgM and IgA antibodies to the recombinant 16-kilodalton antigen of mycobacterium tuberculosis in childhood tuberculosis.
- M. Imaz, M. Comini, +8 authors M. Singh
- Medicine
- The international journal of tuberculosis and…
- 1 November 2001
OBJECTIVE
To evaluate the usefulness of the recombinant 16-kDa antigen (re-Ag16) of Mycobacterium tuberculosis in the serodiagnosis of tuberculosis (TB) in children.
MATERIALS
Seventy-four children… Expand
Depletion of the thioredoxin homologue tryparedoxin impairs antioxidative defence in African trypanosomes.
- M. Comini, R. L. Krauth-Siegel, L. Flohé
- Biology, Medicine
- The Biochemical journal
- 15 February 2007
In trypanosomes, the thioredoxin-type protein TXN (tryparedoxin) is a multi-purpose oxidoreductase that is involved in the detoxification of hydroperoxides, the synthesis of DNA precursors and the… Expand
Trypanothione: a unique bis-glutathionyl derivative in trypanosomatids.
- B. Manta, M. Comini, A. Medeiros, M. Hugo, M. Trujillo, R. Radi
- Biology, Medicine
- Biochimica et biophysica acta
- 1 May 2013
BACKGROUND
Trypanosomatids are early-diverging eukaryotes devoid of the major disulfide reductases - glutathione reductase and thioredoxin reductase - that control thiol-redox homeostasis in most… Expand
The trypanothione system.
- L. Krauth-Siegel, M. Comini, Tanja Schlecker
- Biology, Medicine
- Sub-cellular biochemistry
- 2007
Trypanosomes and Leishmania, the causative agents of severe tropical diseases, employ 2-Cys-peroxiredoxins together with cysteine-homologues of glutathione peroxidases and ascorbate-dependent… Expand