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Redox control in trypanosomatids, parasitic protozoa with trypanothione-based thiol metabolism.
Trypanosomes and leishmania, the causative agents of several tropical diseases, possess a unique redox metabolism which is based on trypanothione. The bis(glutathionyl)spermidine is the central thiolExpand
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Validation of Trypanosoma brucei trypanothione synthetase as drug target.
In trypanosomes, the parasite-specific thiol trypanothione [T(SH)2] fulfills various functions, the best established being detoxification of H2O2 and organic hydroperoxides and ribonucleotideExpand
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Identification of novel bacterial plasminogen‐binding proteins in the human pathogen Mycobacterium tuberculosis
Binding and activation of human plasminogen (Plg) to generate the proteolytic enzyme plasmin (Plm) have been associated with the invasive potential of certain bacteria. In this work, proteomicExpand
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Trypanothione Synthesis in Crithidia Revisited*
In Crithidia fasciculata the biosynthesis of trypanothione (N1,N8-bis(glutathionyl)spermidine; reduced trypanothione), a redox mediator unique to and essential for pathogenic trypanosomatids, wasExpand
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Insights into the redox biology of Trypanosoma cruzi: Trypanothione metabolism and oxidant detoxification.
Trypanosoma cruzi is the etiologic agent of Chagas' disease, an infection that affects several million people in Latin America. With no immediate prospect of a vaccine and problems associated withExpand
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Catalytic mechanism of the glutathione peroxidase-type tryparedoxin peroxidase of Trypanosoma brucei.
Trypanosoma brucei, the causative agent of African sleeping sickness, encodes three nearly identical genes for cysteine-homologues of the selenocysteine-containing glutathione peroxidases. TheExpand
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Evaluation of the diagnostic value of measuring IgG, IgM and IgA antibodies to the recombinant 16-kilodalton antigen of mycobacterium tuberculosis in childhood tuberculosis.
OBJECTIVE To evaluate the usefulness of the recombinant 16-kDa antigen (re-Ag16) of Mycobacterium tuberculosis in the serodiagnosis of tuberculosis (TB) in children. MATERIALS Seventy-four childrenExpand
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Depletion of the thioredoxin homologue tryparedoxin impairs antioxidative defence in African trypanosomes.
In trypanosomes, the thioredoxin-type protein TXN (tryparedoxin) is a multi-purpose oxidoreductase that is involved in the detoxification of hydroperoxides, the synthesis of DNA precursors and theExpand
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Trypanothione: a unique bis-glutathionyl derivative in trypanosomatids.
BACKGROUND Trypanosomatids are early-diverging eukaryotes devoid of the major disulfide reductases - glutathione reductase and thioredoxin reductase - that control thiol-redox homeostasis in mostExpand
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The trypanothione system.
Trypanosomes and Leishmania, the causative agents of severe tropical diseases, employ 2-Cys-peroxiredoxins together with cysteine-homologues of glutathione peroxidases and ascorbate-dependentExpand
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