trypanothione reductase
National Institutes of Health
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Polyamines (PAs) are essential metabolites in eukaryotes, participating in a variety of proliferative processes, and in…
The implementation of a novel sequential computational approach that can be used effectively for virtual screening and…
Trypanothione reductase (TR) is an essential enzyme of trypanosomatids and therefore a promising target for the development of…
Parasitic protozoan species belonging to the genera Trypanosoma and Leishmania are the etiological agents of several diseases in…
The natural lignans veraguensin and grandisin have been reported to be active against Trypanosoma cruzi bloodstream forms. Aiming…
Ajoene ((E,Z)-4,5,9-trithiadodeca-1,6,11-triene 9-oxide), a garlic-derived natural compound, is a covalent inhibitor as well as a…
A prediction algorithm of the binding affinity of ligands to trypanothione reductase (TR), the enzyme replacing glutathione…
The enzyme trypanothione reductase (TR), together with its substrate, the glutathione-spermidine conjugate trypanothione, plays…
Trypanothione reductase (TR) is a flavoenzyme that has been found only in parasitic protozoa of the order Kinetoplastida. The…