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trypanothione reductase

 
National Institutes of Health

Papers overview

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Highly Cited
2011
Highly Cited
2011
Trypanothione reductase (TryR) is a genetically validated drug target in the parasite Trypanosoma brucei, the causative agent of… Expand
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Highly Cited
2011
Highly Cited
2011
In Leishmania the glutathione/glutathione reductase eukaryotic redox sys-tem is replaced by the unique trypanothione… Expand
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Review
2010
Review
2010
Polyamines (PAs) are essential metabolites in eukaryotes, participating in a variety of proliferative processes, and in… Expand
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Highly Cited
2001
Highly Cited
2001
Trypanothione reductase (TR) is both a valid and an attractive target for the design of new trypanocidal drugs. Starting from… Expand
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Highly Cited
2000
Highly Cited
2000
In Kinetoplastida, trypanothione and trypanothione reductase (TRYR) provide an intracellular reducing environment, substituting… Expand
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Highly Cited
1999
Highly Cited
1999
BACKGROUND Trypanothione reductase (TR) helps to maintain an intracellular reducing environment in trypanosomatids, a group of… Expand
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Highly Cited
1998
Highly Cited
1998
Trypanothione reductase (TR), a flavoprotein oxidoreductase central to the unique thiol‐redox system that operates in… Expand
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Highly Cited
1998
Highly Cited
1998
A trans-dominant mutational strategy was used to down-regulate trypanothione reductase (TR) activity levels in Leishmania… Expand
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Highly Cited
1997
Highly Cited
1997
Parasitic protozoa belonging to the order Kinetoplastida contain trypanothione as their major thiol. Trypanothione reductase (TR… Expand
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Highly Cited
1997
Highly Cited
1997
  • D. Horvath
  • Journal of medicinal chemistry
  • 1997
  • Corpus ID: 12936652
A prediction algorithm of the binding affinity of ligands to trypanothione reductase (TR), the enzyme replacing glutathione… Expand
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