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trilostane

Known as: (4Alpha,5alpha,17beta)-4,5-epoxy-3,17-dihydroxyandrost-2-ene-2-carbonitrile, Trilostano, trilostane [Chemical/Ingredient] 
A synthetic derivative of androstane with adrenocortical suppressive properties. Trilostane reversibly inhibits 3 beta-hydroxysteroid dehydrogenase… Expand
National Institutes of Health

Papers overview

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Highly Cited
2008
Highly Cited
2008
OBJECTIVE To evaluate the effects of twice-daily oral administration of a low-dose of trilostane treatment and assess the… Expand
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Highly Cited
2006
Highly Cited
2006
Trilostane is considered an efficacious and safe medication for canine pituitary-dependent hyperadrenocorticism (PDH). Its… Expand
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Highly Cited
2003
Highly Cited
2003
OBJECTIVE To evaluate the efficacy of trilostane in treating dogs with pituitary-dependent hyperadrenocorticism. DESIGN… Expand
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Highly Cited
2002
Highly Cited
2002
The efficacy of trilostane in the treatment of canine pituitary-dependent hyperadrenocorticism (PDH) was evaluated in 78 dogs… Expand
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Highly Cited
2002
Highly Cited
2002
OBJECTIVE To determine the efficacy of trilostane, a 3beta-hydroxysteroid dehydrogenase inhibitor, in dogs with pituitary… Expand
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Highly Cited
2000
Highly Cited
2000
There are conflicting reports on the presence or absence of estrogen receptor (ER) in the primate corpus luteum, and the… Expand
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Highly Cited
1996
Highly Cited
1996
Based on indirect evidence, it has often been assumed that the zona reticularis of the adult human adrenal cortex is the source… Expand
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1983
1983
Five patients with pituitary dependent Cushing's syndrome and two with adrenal carcinoma were treated with increasing doses of… Expand
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Highly Cited
1978
Highly Cited
1978
Trilostane is a competitive inhibitor of 3beta-hydroxysteroid dehydrogenase. In vitro, the drug inhibits conversion of… Expand
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Highly Cited
1978
Highly Cited
1978
Seven patients with Cushing's syndrome were treated with trilostane (WIN 24,540) 4 alpha,5-epoxy-17 beta-hydroxy-3-oxo-5 alpha… Expand
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