trilostane

Known as: (4Alpha,5alpha,17beta)-4,5-epoxy-3,17-dihydroxyandrost-2-ene-2-carbonitrile, Trilostano, trilostane [Chemical/Ingredient] 
A synthetic derivative of androstane with adrenocortical suppressive properties. Trilostane reversibly inhibits 3 beta-hydroxysteroid dehydrogenase… (More)
National Institutes of Health

Papers overview

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2006
2006
Trilostane is thought to be a competitive inhibitor of the 3beta-hydroxysteroid dehydrogenase (3beta-HSD), an essential enzyme… (More)
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2004
2004
Sixteen Pomeranians and eight miniature poodles presenting with clinical signs of alopecia X, elevated blood concentrations of 17… (More)
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2003
2003
OBJECTIVE To evaluate the efficacy of trilostane in treating dogs with pituitary-dependent hyperadrenocorticism. DESIGN… (More)
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2003
2003
REASONS FOR PERFORMING STUDY Trilostane, a competitive 3-beta hydroxysteroid dehydrogenase inhibitor, has been used successfully… (More)
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Highly Cited
2002
Highly Cited
2002
The efficacy of trilostane in the treatment of canine pituitary-dependent hyperadrenocorticism (PDH) was evaluated in 78 dogs… (More)
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Highly Cited
1989
Highly Cited
1989
Cells dissociated from newborn rat forebrains were established in long term primary cultures. The cultures were made up almost… (More)
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1985
1985
Trilostane, an inhibitor of the 3 beta-hydroxysteroid dehydrogenase enzyme system of steroid biosynthesis, was applied to 18… (More)
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1983
1983
Trilostane has been used to treat 6 patients with Cushing's syndrome, 4 with an adrenal adenoma and 2 with pituitary driven… (More)
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1983
1983
Five patients with pituitary dependent Cushing's syndrome and two with adrenal carcinoma were treated with increasing doses of… (More)
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Highly Cited
1978
Highly Cited
1978
Trilostane is a competitive inhibitor of 3beta-hydroxysteroid dehydrogenase. In vitro, the drug inhibits conversion of… (More)
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