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Life Cycle Heterogeneity in Animal Models of Human Papillomavirus-Associated Disease
Of the model systems examined here, only ROPV had a tissue tropism and a life cycle organization that resembled those of the human mucosal types and appears most appropriate for studies of the life cycles of mucosal papillomavirus types and for the development of prophylactic vaccines.
The molecular basis of mouse adaptation by human enterovirus 71.
- B. Chua, P. Phuektes, S. Sanders, P. Nicholls, P. McMinn
- Biology, MedicineThe Journal of general virology
- 1 July 2008
Infectious cDNA clone-derived mutant virus populations containing the mutations identified in CHO-26M and MP- 26M were generated in order to study the molecular basis of CHO cell and mouse adaptation.
Trypanosomes genetic diversity, polyparasitism and the population decline of the critically endangered Australian marsupial, the brush tailed bettong or woylie (Bettongia penicillata)
Intra-epithelial vaccination with COPV L1 DNA by particle-mediated DNA delivery protects against mucosal challenge with infectious COPV in beagle dogs.
A Novel Virus Detected in Papillomas and Carcinomas of the Endangered Western Barred Bandicoot (Perameles bougainville) Exhibits Genomic Features of both the Papillomaviridae and Polyomaviridae
A novel virus is detected in lesional tissue from affected western barred bandicoots using multiply primed rolling-circle amplification and PCR with the cutaneotropic papillomavirus primer pairs FAP59/FAP64 and AR-L1F8/AR-L 1R9, and this virus may represent the first member of a novel virus family descended from a common ancestor of the papillsomaviruses and polyomviruses recognized today.
The immunology of animal papillomaviruses.
Regression of canine oral papillomas is associated with infiltration of CD4+ and CD8+ lymphocytes.
Immunohistochemical analysis of the timing and phenotype of immune cell infiltration revealed a marked influx of leukocytes during wart regression, including abundant CD4+ and CD8+ cells, withCD4+ cells being most numerous.
Naturally occurring, nonregressing canine oral papillomavirus infection: host immunity, virus characterization, and experimental infection.
The hypothesis that the recurrent lesions seen in some human papilomavirus infections, such as recurrent laryngeal papillomatosis, are associated with specific defects in host immunity rather than variations in viral pathogenicity is supported.
Remission of histiocytic ulcerative colitis in Boxer dogs correlates with eradication of invasive intramucosal Escherichia coli.
- C. Mansfield, F. James, K. Simpson
- Biology, MedicineJournal of veterinary internal medicine
- 1 September 2009
The correlation between clinical remission and the eradication of mucosally invasive E. coli during treatment with enrofloxacin supports the causal involvement of E. bacteria in the development of HUC in susceptible Boxer dogs.