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Dihydrotestosterone

Known as: (5alpha,17beta)-17-Hydroxyandrostan-3-one, 5alpha-Dihydrotestosterone, 5 alpha DHT 
The most potent androgen, required for sex development. Dihydrotestosterone is synthesized from testosterone in the prostate gland, testes, hair… 
National Institutes of Health

Related topics

Related topics

34 relations

Narrower (20)

17-hydroxyandrostan-19-ol-3-one17-ketotrilostane18F-MDHT2,17-dimethyldihydrotestosterone

Broader (1)

Androgens
Androstanolone:MCnc:Pt:Ser/Plas:QnAndrostanolone:PrThr:Pt:Ser/Plas:OrdAndrostanolone:SCnc:Pt:Ser/Plas:QnDihydroepitestosterone

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2010
Highly Cited
2010
Antitumour activity of MDV3100 in castration-resistant prostate cancer: a phase 1–2 study
Review
2007
Review
2007
Sexual behavior in male rodents
Highly Cited
1998
Highly Cited
1998
The effect of six months treatment with a 100 mg daily dose of dehydroepiandrosterone (DHEA) on circulating sex steroids, body composition and muscle strength in age‐advanced men and women
The biological role of the adrenal sex steroid precursors ‐ DHEA and DHEA sulphate (DS) and their decline with ageing remains… 
Highly Cited
1994
Highly Cited
1994
Effects of replacement dose of dehydroepiandrosterone in men and women of advancing age.
Aging in humans is accompanied by a progressive decline in the secretion of the adrenal androgens dehydroepiandrosterone (DHEA… 
Highly Cited
1992
Highly Cited
1992
Tissue distribution and kinetic characteristics of rat steroid 5 alpha-reductase isozymes. Evidence for distinct physiological functions.
Highly Cited
1990
Highly Cited
1990
Testosterone at high concentrations interacts with the human androgen receptor similarly to dihydrotestosterone.
Testosterone and dihydrotestosterone are believed to exert their androgenic effects by interacting with a single intracellular… 
Highly Cited
1979
Highly Cited
1979
Establishment and characterization of a cell line of human breast carcinoma origin.
Highly Cited
1975
Highly Cited
1975
The determination of five steroids in avian plasma by radioimmunoassay and competitive protein-binding
Highly Cited
1975
Highly Cited
1975
MCF-7: A human breast cancer cell line with estrogen, androgen, progesterone, and glucocorticoid receptors
Highly Cited
1970
Highly Cited
1970
Dihydrotestosterone in prostatic hypertrophy. I. The formation and content of dihydrotestosterone in the hypertrophic prostate of man.
To explore the relation between androgens and prostatic hypertrophy in man, the concentrations of testosterone… 
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