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tranilast

Known as: 2-((3-(3,4-dimethoxyphenyl)-1-oxo-2-propenyl)amino)benzoic acid, 2-{[(2E)-3-(3,4-dimethoxyphenyl)prop-2-enoyl]amino}benzoic acid, N-(3',4'-dimethoxycinnamoyl)anthranilic acid 
National Institutes of Health

Related topics

Related topics

6 relations

Broader (6)

Anti-Allergic AgentsAnti-Inflammatory Agents, Non-SteroidalCalcium Channel BlockersHistamine H1 Antagonists

Papers overview

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2009
2009
Tranilast strongly sensitizes pancreatic cancer cells to gemcitabine via decreasing protein expression of ribonucleotide reductase 1.
Gemcitabine (Gem) is a dFdC analogue with activity against several solid tumors. Gem is intracellularly phosphorylated by dCK… 
2007
2007
Long-term prospective pilot study with tranilast for the prevention of stricture progression in patients with Crohn’s disease
Fibrosis and strictures are common and irreversible complications of Crohn’s disease that potentially necessitate bowel resection… 
2004
2004
Arterial and venous smooth-muscle cells differ in their responses to antiproliferative drugs.
2004
2004
Effect of tranilast on matrix metalloproteinase-1 secretion from human gingival fibroblasts in vitro.
BACKGROUND Some drugs such as phenytoin, calcium blockers, or cyclosporins are known to cause gingival fibrous hyperplasia, an… 
Highly Cited
1996
Highly Cited
1996
Inhibitory effects of tranilast on proliferation, migration, and collagen synthesis of human vascular smooth muscle cells.
The aim of this study was to examine the effects of tranilast (anti-allergic drug) on proliferation, migration, and collagen… 
1996
1996
Antiproliferative and c‐myc mRNA suppressive effects of tranilast on newborn human vascular smooth muscle cells in culture
1 Newborn human vascular smooth muscle cells (VSMCs) proliferated faster and were more sensitive to platelet‐derived growth… 
1987
1987
The effect of tranilast of the generation of reactive oxygen species.
The relative in vitro antioxidant efficacy of tranilast, a new orally active anti-allergic agent, was examined by studying its… 
1987
1987
Effect of OKY-046, a new thromboxane A2 synthetase inhibitor, on experimental asthma in guinea pigs.
1986
1986
Successful Treatment of Cheilitis Granulomatosa with Tranilast
A new anti‐allergic drug, tranilast [N‐(3′,4′‐dimethoxycinnamoyl) anthranilic acid] was used on a 46‐year‐old Japanese female… 
1985
1985
Hyaluronidase-inhibitory and anti-allergic activities of the photo-irradiated products of tranilast.
We found that N-(trans-3, 4-dimethoxycinnamoyl) anthranilic acid (tranilast) is readily transformed by photo-irradiation to N… 
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