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tranilast
Known as:
2-((3-(3,4-dimethoxyphenyl)-1-oxo-2-propenyl)amino)benzoic acid
, 2-{[(2E)-3-(3,4-dimethoxyphenyl)prop-2-enoyl]amino}benzoic acid
, N-(3',4'-dimethoxycinnamoyl)anthranilic acid
National Institutes of Health
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Related topics
Related topics
6 relations
Broader (6)
Anti-Allergic Agents
Anti-Inflammatory Agents, Non-Steroidal
Calcium Channel Blockers
Histamine H1 Antagonists
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Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2009
2009
Tranilast strongly sensitizes pancreatic cancer cells to gemcitabine via decreasing protein expression of ribonucleotide reductase 1.
Mayumi Mitsuno
,
Y. Kitajima
,
+6 authors
K. Miyazaki
International Journal of Oncology
2009
Corpus ID: 1013041
Gemcitabine (Gem) is a dFdC analogue with activity against several solid tumors. Gem is intracellularly phosphorylated by dCK…
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2007
2007
Glucuronidation of Antiallergic Drug, Tranilast: Identification of Human UDP-Glucuronosyltransferase Isoforms and Effect of Its Phase I Metabolite
M. Katoh
,
Tomohito Matsui
,
T. Yokoi
Drug Metabolism And Disposition
2007
Corpus ID: 10466917
Tranilast is an oral antiallergic agent widely used in Japan. Recently, in Western populations, hyperbilirubinemia induced by…
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2004
2004
Effect of tranilast on matrix metalloproteinase-1 secretion from human gingival fibroblasts in vitro.
E. Maita
,
Mami Sato
,
K. Yamaki
The Journal of Periodontology
2004
Corpus ID: 19980056
BACKGROUND Some drugs such as phenytoin, calcium blockers, or cyclosporins are known to cause gingival fibrous hyperplasia, an…
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2001
2001
Tranilast Inhibits Cardiac Allograft Vasculopathy in Association With p21Waf1/Cip1 Expression on Neointimal Cells in Murine Cardiac Transplantation Model
A. Izawa
,
J. Suzuki
,
W. Takahashi
,
J. Amano
,
M. Isobe
Arteriosclerosis, Thrombosis and Vascular Biology
2001
Corpus ID: 9544739
Cardiac allograft vasculopathy is a major complication after cardiac transplantation, often limiting long-term recipient survival…
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Highly Cited
1996
Highly Cited
1996
Inhibitory effects of tranilast on proliferation, migration, and collagen synthesis of human vascular smooth muscle cells.
J. Fukuyama
,
Keiji Miyazawa
,
Shuichiro Hamano
,
Arao Ujiie
Canadian Journal of Physiology and Pharmacology
1996
Corpus ID: 10331822
The aim of this study was to examine the effects of tranilast (anti-allergic drug) on proliferation, migration, and collagen…
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1996
1996
Antiproliferative and c‐myc mRNA suppressive effects of tranilast on newborn human vascular smooth muscle cells in culture
K. Miyazawa
,
S. Hamano
,
A. Ujiie
British Journal of Pharmacology
1996
Corpus ID: 26178794
1 Newborn human vascular smooth muscle cells (VSMCs) proliferated faster and were more sensitive to platelet‐derived growth…
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1987
1987
The effect of tranilast of the generation of reactive oxygen species.
Y. Miyachi
,
S. Imamura
,
Y. Niwa
Journal of Pharmacobio-Dynamics
1987
Corpus ID: 37289033
The relative in vitro antioxidant efficacy of tranilast, a new orally active anti-allergic agent, was examined by studying its…
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1987
1987
Effect of OKY-046, a new thromboxane A2 synthetase inhibitor, on experimental asthma in guinea pigs.
Nagai
,
Hiroichi
,
+15 authors
Masayuki
Prostaglandins Leukotrienes and Medicine
1987
Corpus ID: 46459391
1986
1986
Successful Treatment of Cheilitis Granulomatosa with Tranilast
Taizo Kato
,
H. Tagami
Journal of dermatology (Print)
1986
Corpus ID: 24758632
A new anti‐allergic drug, tranilast [N‐(3′,4′‐dimethoxycinnamoyl) anthranilic acid] was used on a 46‐year‐old Japanese female…
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1985
1985
Hyaluronidase-inhibitory and anti-allergic activities of the photo-irradiated products of tranilast.
H. Kakegawa
,
N. Mitsuo
,
H. Matsumoto
,
T. Satoh
,
M. Akagi
,
K. Tasaka
Chemical and pharmaceutical bulletin
1985
Corpus ID: 30672248
We found that N-(trans-3, 4-dimethoxycinnamoyl) anthranilic acid (tranilast) is readily transformed by photo-irradiation to N…
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