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tranilast

Known as: 2-((3-(3,4-dimethoxyphenyl)-1-oxo-2-propenyl)amino)benzoic acid, 2-{[(2E)-3-(3,4-dimethoxyphenyl)prop-2-enoyl]amino}benzoic acid, N-(3',4'-dimethoxycinnamoyl)anthranilic acid 
National Institutes of Health

Related topics

Related topics

6 relations

Broader (6)

Anti-Allergic AgentsAnti-Inflammatory Agents, Non-SteroidalCalcium Channel BlockersHistamine H1 Antagonists

Papers overview

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2009
2009
Tranilast strongly sensitizes pancreatic cancer cells to gemcitabine via decreasing protein expression of ribonucleotide reductase 1.
Gemcitabine (Gem) is a dFdC analogue with activity against several solid tumors. Gem is intracellularly phosphorylated by dCK… 
2007
2007
Glucuronidation of Antiallergic Drug, Tranilast: Identification of Human UDP-Glucuronosyltransferase Isoforms and Effect of Its Phase I Metabolite
Tranilast is an oral antiallergic agent widely used in Japan. Recently, in Western populations, hyperbilirubinemia induced by… 
2004
2004
Effect of tranilast on matrix metalloproteinase-1 secretion from human gingival fibroblasts in vitro.
BACKGROUND Some drugs such as phenytoin, calcium blockers, or cyclosporins are known to cause gingival fibrous hyperplasia, an… 
2001
2001
Tranilast Inhibits Cardiac Allograft Vasculopathy in Association With p21Waf1/Cip1 Expression on Neointimal Cells in Murine Cardiac Transplantation Model
Cardiac allograft vasculopathy is a major complication after cardiac transplantation, often limiting long-term recipient survival… 
Highly Cited
1996
Highly Cited
1996
Inhibitory effects of tranilast on proliferation, migration, and collagen synthesis of human vascular smooth muscle cells.
The aim of this study was to examine the effects of tranilast (anti-allergic drug) on proliferation, migration, and collagen… 
1996
1996
Antiproliferative and c‐myc mRNA suppressive effects of tranilast on newborn human vascular smooth muscle cells in culture
1 Newborn human vascular smooth muscle cells (VSMCs) proliferated faster and were more sensitive to platelet‐derived growth… 
1987
1987
The effect of tranilast of the generation of reactive oxygen species.
The relative in vitro antioxidant efficacy of tranilast, a new orally active anti-allergic agent, was examined by studying its… 
1987
1987
Effect of OKY-046, a new thromboxane A2 synthetase inhibitor, on experimental asthma in guinea pigs.
1986
1986
Successful Treatment of Cheilitis Granulomatosa with Tranilast
A new anti‐allergic drug, tranilast [N‐(3′,4′‐dimethoxycinnamoyl) anthranilic acid] was used on a 46‐year‐old Japanese female… 
1985
1985
Hyaluronidase-inhibitory and anti-allergic activities of the photo-irradiated products of tranilast.
We found that N-(trans-3, 4-dimethoxycinnamoyl) anthranilic acid (tranilast) is readily transformed by photo-irradiation to N… 
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