• Publications
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Dendritic cells differently respond to haptens and irritants by their production of cytokines and expression of co‐stimulatory molecules
After application of haptens to the skin, Langerhans cells (LC), i.e. immature dendritic cells (DC) in the skin, move to secondary lymphoid organs to sensitize naive T cells. During this process, LCExpand
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p38 Mitogen-activated protein kinase and extracellular signal-regulated kinases play distinct roles in the activation of dendritic cells by two representative haptens, NiCl2 and
Previous studies have demonstrated that haptens induce several phenotypic and functional changes of dendritic cells in vivo as well as in vitro. Although recently, the crucial role of p38Expand
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High commitment of embryonic keratinocytes to terminal differentiation through a Notch1-caspase 3 regulatory mechanism.
Embryonic cells are expected to possess high growth/differentiation potential, required for organ morphogenesis and expansion during development. However, little is known about the intrinsicExpand
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Location‐related differences in structure and function of the stratum corneum with special emphasis on those of the facial skin
  • H. Tagami
  • Medicine, Chemistry
  • International journal of cosmetic science
  • 1 December 2008
Between the two different kinds of the skin covering the body, the glabrous skin is found only on the palmo‐plantar surface because of its rather simple function to protect the underlying livingExpand
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Evaluation of the skin surface hydration in vivo by electrical measurement.
Nobody denies the fact that cracking and scaling of the skin surface develop because of decreased water content in the horny layer. However, functional research of such stratum corneum has beenExpand
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Functional properties of the stratum corneum in patients with diabetes mellitus: similarities to senile xerosis
Background  Although diabetes mellitus is known to induce many pathophysiological changes in the skin, none of the earlier studies has focused on the state of the stratum corneum (SC) in patientsExpand
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The safety assessment of fragrance materials.
Safety evaluation of the large number of diverse chemicals used as fragrance ingredients follows a systematic prioritization of data generation and analysis, consideration of exposure and criticalExpand
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  • Open Access
A toxicologic and dermatologic assessment of cinnamyl alcohol, cinnamaldehyde and cinnamic acid when used as fragrance ingredients.
a Department of Dermatology, College of Physicians and Surgeons of Columbia University, 161 Fort Washington Avenue, New York, NY 10032, USA b Department of Animal and Plant Sciences, The UniversityExpand
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  • Open Access
Notch signaling: its role in epidermal homeostasis and in the pathogenesis of skin diseases.
Skin undergoes self-renewal throughout life. Terminally differentiated keratinocytes, namely the corneocytes, are continually shed from the surface of the skin, whereas immature cells produce progenyExpand
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Activated Protein C Reduces the Ischemia/Reperfusion-Induced Spinal Cord Injury in Rats by Inhibiting Neutrophil Activation
ObjectiveTo examine whether activated protein C (APC) reduces spinal cord injury in rats by inhibiting neutrophil activation after the transient ischemia. Summary Background DataIschemic spinal cordExpand
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