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Mst1 inhibits autophagy by promoting the interaction between Beclin1 and Bcl-2
Here we show that Mst1, a proapoptotic kinase, impairs protein quality control mechanisms in the heart through inhibition of autophagy. Stress-induced activation of Mst1 in cardiomyocytes promotedExpand
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Prognostic determinants of long-term survival in Japanese patients with cardiac sarcoidosis treated with prednisone.
Cardiac involvement is an important prognostic factor in sarcoidosis, but reliable indicators of mortality risk in cardiac sarcoidosis are unstudied in a large number of patients. To determine theExpand
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Assessment of acute injuries and chronic intimal thickening of the radial artery after transradial coronary intervention by optical coherence tomography.
AIMS Transradial coronary intervention (TRI) introduces a trauma to the radial artery (RA), possibly influencing quality as a bypass conduit if subsequently used. We sought to determine the acute andExpand
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Comparison of clinical features and prognosis of cardiac sarcoidosis and idiopathic dilated cardiomyopathy.
In the present study, clinical findings of 15 patients with cardiac sarcoidosis presenting as dilated cardiomyopathy were compared with those of 30 consecutive patients with idiopathic dilatedExpand
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Improved prognosis of Takayasu arteritis over the past decade--comprehensive analysis of 106 patients.
BACKGROUND We aimed to describe the recent clinical characteristics of Takayasu arteritis (TA). METHODS AND RESULTS We enrolled 106 consecutive TA patients and compared the clinical characteristicsExpand
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Progesterone Regulates Cardiac Repolarization Through a Nongenomic Pathway: An In Vitro Patch-Clamp and Computational Modeling Study
Background— Female sex is an independent risk factor for torsade de pointes in long-QT syndrome. In women, QT interval and torsade de pointes risk fluctuate dynamically during the menstrual cycle andExpand
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Diagnosis and assessment of Takayasu arteritis by multiple biomarkers.
BACKGROUND Patients with Takayasu arteritis (TA) often show recurrence under steroid treatment without an elevation of C-reactive protein (CRP). There is a report that matrix metalloproteinaseExpand
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Induction of premature senescence in cardiomyocytes by doxorubicin as a novel mechanism of myocardial damage
Cellular senescence is an important phenomenon in decreased cellular function. Recently, it was shown that cellular senescence is induced in proliferating cells within a short period of time byExpand
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Clinical Implications of Reconnection Between the Left Atrium and Isolated Pulmonary Veins Provoked by Adenosine Triphosphate after Extensive Encircling Pulmonary Vein Isolation
Introduction: Dormant pulmonary vein (PV) conduction can be provoked by adenosine triphosphate (ATP) after extensive encircling pulmonary vein isolation (EEPVI). However, the clinical implication ofExpand
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Integrating Genetic, Transcriptional, and Functional Analyses to Identify 5 Novel Genes for Atrial Fibrillation
Background— Atrial fibrillation (AF) affects >30 million individuals worldwide and is associated with an increased risk of stroke, heart failure, and death. AF is highly heritable, yet the geneticExpand
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