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RATIONALE Syndecan-4 (Syn4), a cell-surface heparan sulfate proteoglycan, has been detected in the infarct region after myocardial infarction (MI), but its functional significance has not been elucidated. OBJECTIVE We examined whether and how Syn4 regulates the cardiac healing process after MI. METHODS AND RESULTS Although the heart in Syn4-deficient(More)
Tenascin-X (TNX) is an extracellular matrix glycoprotein. We previously demonstrated that TNX regulates the expression of type VI collagen. In this study, we investigated the binding of TNX to type I collagen as well as to type VI collagen and the effects of these proteins on fibrillogenesis of type I collagen. Full-length recombinant TNX, which is(More)
R-Ras is a Ras-family small GTPase that regulates various cellular functions such as apoptosis and cell adhesion. Here, we demonstrate a role of R-Ras in exocytosis. By the use of specific anti-R-Ras antibody, we found that R-Ras was enriched on both early and recycling endosomes in a wide range of cell lines. Using a fluorescence resonance energy(More)
The results of our previous study showed that tumor invasion and metastasis are promoted in extracellular matrix (ECM) tenascin-X-deficient (TNX-/-) mice via increased expression of matrix metalloproteinases (MMPs). However, little is known about the relationship between TNX deficiency and activation of MMP genes. In this study, we investigated the(More)
The cystine/glutamate transporter, designated as system xc(-), is important for maintaining intracellular glutathione levels and extracellular redox balance. The substrate-specific component of system xc(-), xCT, is strongly induced by various stimuli, including oxidative stress, whereas it is constitutively expressed only in specific brain regions and(More)
BACKGROUND Some drugs such as phenytoin, calcium blockers, or cyclosporins are known to cause gingival fibrous hyperplasia, an unwanted side effect. Decreased collagen catabolism in overgrown gingival tissue has been proposed as one of the reasons causing the disease. The effect of tranilast, which suppresses collagen synthesis and cell proliferation, on(More)
Liesegang rings based on a chemical reaction, not a conventional precipitation reaction, have been developed by appropriate design of the nucleation dynamics in a system involving complex formation in a matrix. The periodic and concentric rings consisted of well-dispersed Ag nanoparticles with diameters of a few nanometers. The approach modeled here could(More)
A one-directional flow induced by chemical wave propagation was investigated to understand the origin of its dynamic flow. A cylindrical injection port was connected with a straight propagation channel; the chemical wave was initiated at the injection port. Chemical waves propagated with a constant velocity irrespective of the channel width, indicating that(More)
Tenascin-X (TNX) is an extracellular matrix protein that is highly expressed in the peripheral nervous system as well as muscular tissues, especially the heart and skeletal muscle. However, the expression manner and the physiological role of TNX in the peripheral nervous system have not been fully investigated. In this study, we elucidated its distribution(More)
Rationale: Syndecan-4 (Syn4), a cell-surface heparan sulfate proteoglycan, has been detected in the infarct region after myocardial infarction (MI), but its functional significance has not been elucidated. ؊/؊) mice was morphologically and functionally normal, Syn4 ؊/؊ mice exhibited impaired heart function and increased mortality rate as a result of(More)