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tifluadom

Known as: 1-methyl-2-(3-thienylcarbonyl)aminomethyl-5-(2-fluorophenyl)-H-2,3-dihydro-1,4-benzodiazepine, 3-Thiophenecarboxamide, N-((5-(2-fluorophenyl)-2,3-dihydro-1-methyl-1H-1,4-benzodiazepin-2-yl)methyl)-, titfluadom 
National Institutes of Health

Related topics

Related topics

5 relations

Broader (2)

BenzodiazepinesDiuretics

Narrower (3)

KC 5103KC 5911KC 6128

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
1997
Highly Cited
1997
Activation of the cloned human kappa opioid receptor by agonists enhances [35S]GTPgammaS binding to membranes: determination of potencies and efficacies of ligands.
Activation of kappa receptors inhibits adenylate cyclase, enhances K+ conductance and reduces Ca++ conductance via pertussis… 
Highly Cited
1989
Highly Cited
1989
Kappa opiate receptor multiplicity: evidence for two U50,488-sensitive kappa 1 subtypes and a novel kappa 3 subtype.
Kappa receptor multiplicity is a complex area. We now present evidence from binding studies suggesting the existence of four… 
Highly Cited
1988
Highly Cited
1988
Opposite effects of mu and kappa opiate agonists on dopamine release in the nucleus accumbens and in the dorsal caudate of freely moving rats.
We studied the effect of opiates acting preferentially on mu receptors, like morphine, methadone and fentanyl (mu agonists) and… 
Highly Cited
1988
Highly Cited
1988
Effect of kappa-opioid receptor agonists on morphine analgesia in morphine-naive and morphine-tolerant rats.
Highly Cited
1987
Highly Cited
1987
Kappa opioids in rhesus monkeys. I. Diuresis, sedation, analgesia and discriminative stimulus effects.
The effects of the kappa agonists bremazocine, ethylketazocine, tifluadom and U-50,488 were examined in rhesus monkeys with four… 
Highly Cited
1986
Highly Cited
1986
Effects of kappa opiate agonists on neurochemical and neuroendocrine indices: evidence for kappa receptor subtypes.
1985
1985
Effects of kappa opiate agonists on palatable food consumption in non-deprived rats, with and without food preloads
Highly Cited
1983
Highly Cited
1983
Opiate receptors in the rat vas deferens.
Highly Cited
1982
Highly Cited
1982
An opioid benzodiazepine
Although the benzodiazepines have been extensively investigated since their discovery about 20 years ago1, only recently have… 
Highly Cited
1982
Highly Cited
1982
Unexpected opioid activity in a known class of drug.
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