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The pharmacological properties of a new, orally active antianaphylactic compound: ketotifen, a benzocycloheptathiophene.
Bremazocine: a potent, long-acting opiate kappa-agonist.
Pharmacological evaluation of mild analgesics.
- D. Römer
- Medicine, ChemistryBritish journal of clinical pharmacology
The inflamed paw technique and the adjuvant arthritis model, both in the rat and involving pathological (chronic) pain, are the most successful methods of predicting analgesic activity in man.
Unexpected opioid activity in a known class of drug.
Evidence for analgesic activity of enkephalin in the mouse
It is indicated that the two natural compounds induce analgesia in mice, whereas the two analogues are devoid of such activity.
An opioid benzodiazepine
Although the benzodiazepines have been extensively investigated since their discovery about 20 years ago1, only recently have antagonists of the classical actions of benzodiazepines been described2.…
Inhibitory effect of a new opioid agonist on reproductive endocrine activity in rats of both sexes.
CY 208-243: a unique combination of atypical opioid antinociception and D1 dopaminomimetic properties.
Comparison of the self-administration liabilities of morphine and pentazocine in the rhesus monkey [proceedings].
The results indicate that pentazocine produced a mild degree of physical dependence that was quantitatively and in some aspects qualitatively different to that exhibited by morphine.