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Unexpected opioid activity in a known class of drug.
TLDR
Tifluadom is characterised as an opiate kappa-receptor agonist in vitro and in vivo with potent analgesic activity in animals and no dependence potential. Expand
An opioid benzodiazepine
Although the benzodiazepines have been extensively investigated since their discovery about 20 years ago1, only recently have antagonists of the classical actions of benzodiazepines been described2.Expand
Trimethoprim-Sulfamethoxazole-Induced Cholestatic Hepatitis: Inadvertent Rechallenge.
TLDR
A case involving the inadvertent rechallenge with trimethoprim-sulfamethoxazole (Bactrim) in a patient with a previous episode of drug-induced hepatitis is reported. Expand
The Structure of New Valepotriates from Tissue Cultures of Valeriana wallichii.
TLDR
Colchicin-treated tissue cultures of VALERIANA WALLICHII produced several unknown substances of diene-valepotriate structure that were isolated and their structure elucidated by means of their (13)C-NMR spectra. Expand
On the active agents of Valerian.
TLDR
The structures of well known and of new valepotriathydrines have been clarified and a characteristic dependence on type and position of the acyloxy substituents is shown. Expand
AN OPIOID BENZODIAZEPINE
A 13C-NMR study of the structure of an acyl-linarin from Valeriana wallichii
Abstract An acylated acacetin-7- O -rutinoside of Valeriana wallichii has been shown to be a mixture of its 2‴- O -and 3‴- O -2-methylbutyryl esters by 13 C-NMR, GLC, and MS.
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