Unexpected opioid activity in a known class of drug.

@article{Rmer1982UnexpectedOA,
  title={Unexpected opioid activity in a known class of drug.},
  author={D. R{\"o}mer and H. B{\"u}scher and R. C. Hill and R. Maurer and T. Petcher and H. Zeugner and W. Benson and E. Finner and W. Milkowski and P. Thies},
  journal={Life sciences},
  year={1982},
  volume={31 12-13},
  pages={
          1217-20
        }
}
Tifluadom, although structurally a 1,4 benzodiazepine, has no affinity for the 3H-flunitrazepam binding site, but is a potent displacer of 3H-bremazocine from its opioid binding site. Tifluadom is characterised as an opiate kappa-receptor agonist in vitro and in vivo with potent analgesic activity in animals and no dependence potential. 
The role of opioid receptor sub‐types in tifluadom‐induced feeding
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