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thrombin receptor peptide (42-47)

Known as: SFLLRN, thrombin (42-47) peptide, seryl-phenylalanyl--leucyl-leucyl-arginyl-asparagine 
 
National Institutes of Health

Topic mentions per year

Topic mentions per year

1992-2018
010203019922018

Related topics

Related topics

1 relation

Broader (1)

Peptide Fragments

Related mentions per year

Related mentions per year

1948-2018
19401960198020002020
thrombin receptor peptide (42-47)
Peptide Fragments

Papers overview

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Highly Cited
2005
Highly Cited
2005
Functional selectivity of G protein signaling by agonist peptides and thrombin for the protease-activated receptor-1.
Thrombin activates protease-activated receptor-1 (PAR-1) by cleavage of the amino terminus to unmask a tethered ligand. Although… (More)
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Highly Cited
2005
Highly Cited
2005
PAR-1 activation on human late endothelial progenitor cells enhances angiogenesis in vitro with upregulation of the SDF-1/CXCR4 system.
OBJECTIVE The importance of PAR-1 in blood vessel development has been demonstrated in knockout mice. As endothelial progenitor… (More)
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Highly Cited
2002
Highly Cited
2002
Participation of protease-activated receptor-1 in thrombin-induced microglial activation.
Activation of microglia, the resident macrophages in the CNS, plays a significant role in neuronal death or degeneration in a… (More)
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Highly Cited
2001
Highly Cited
2001
Thrombin suppresses endothelial nitric oxide synthase and upregulates endothelin-converting enzyme-1 expression by distinct pathways: role of Rho/ROCK and mitogen-activated protein kinase.
An imbalance of nitric oxide and endothelin plays an important role in cardiovascular disease. Thrombin exerts profound effects… (More)
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Highly Cited
2000
Highly Cited
2000
Potentiation of NMDA receptor function by the serine protease thrombin.
Although serine proteases and their receptors are best known for their role in blood coagulation and fibrinolysis, the CNS… (More)
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Highly Cited
1999
Highly Cited
1999
Activated platelets release two types of membrane vesicles: microvesicles by surface shedding and exosomes derived from exocytosis of multivesicular bodies and alpha-granules.
Platelet activation leads to secretion of granule contents and to the formation of microvesicles by shedding of membranes from… (More)
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Highly Cited
1999
Highly Cited
1999
Enhanced levels of soluble and membrane-bound CD40 ligand in patients with unstable angina. Possible reflection of T lymphocyte and platelet involvement in the pathogenesis of acute coronary…
BACKGROUND The CD40 ligand (CD40L) on activated T cells and platelets may be activating matrix metalloproteinases, inducing… (More)
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Highly Cited
1999
Highly Cited
1999
Activated Platelets Release Two Types of Membrane Vesicles: Microvesicles by Surface Shedding and Exosomes Derived From Exocytosis of Multivesicular Bodies and a-Granules
Platelet activation leads to secretion of granule contents and to the formation of microvesicles by shedding of membranes from… (More)
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Highly Cited
1996
Highly Cited
1996
p38 mitogen-activated protein kinase phosphorylates cytosolic phospholipase A2 (cPLA2) in thrombin-stimulated platelets. Evidence that proline-directed phosphorylation is not required for…
The Ca2+-sensitive 85-kDa cytosolic phospholipase A2 (cPLA2) is responsible for thrombin-stimulated mobilization of arachidonic… (More)
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Highly Cited
1993
Highly Cited
1993
Internalization and recycling of activated thrombin receptors.
Shortly after activation by either thrombin or the tethered ligand domain peptide SFLLRN, thrombin receptors undergo homologous… (More)
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