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- Influence
YC-1, a novel activator of platelet guanylate cyclase.
YC-1 [3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole] inhibited the aggregation of and ATP release from washed rabbit platelets induced by arachidonic acid (AA), collagen, U46619, platelet-activating… Expand
YC-1 inhibits HIF-1 expression in prostate cancer cells: contribution of Akt/NF-kappaB signaling to HIF-1alpha accumulation during hypoxia.
Hypoxia-inducible factor 1 (HIF-1), a transcription factor that is critical for tumor adaptation to microenvironmental stimuli, represents an attractive chemotherapeutic target. YC-1 is a novel… Expand
Enhancement of long-term potentiation by a potent nitric oxide-guanylyl cyclase activator, 3-(5-hydroxymethyl-2-furyl)-1-benzyl-indazole.
- Wei-Lin Chien, K. Liang, C. Teng, S. Kuo, F. Lee, W. Fu
- Chemistry, Medicine
- Molecular pharmacology
- 1 June 2003
Nitric oxide (NO) is known to affect synaptic plasticity in various regions of the brain via the cGMP-cGMP-dependent protein kinase (PKG) pathway. We found that a novel compound… Expand
Antioxidant properties of butein isolated from Dalbergia odorifera.
- Z. Cheng, S. Kuo, S. C. Chan, F. Ko, C. Teng
- Chemistry, Medicine
- Biochimica et biophysica acta
- 15 June 1998
The antioxidant properties of butein, isolated from Dalbergia odorifera T. Chen, were investigated in this study. Butein inhibited iron-induced lipid peroxidation in rat brain homogenate in a… Expand
YC‐1 inhibited human platelet aggregation through NO‐independent activation of soluble guanylate cyclase
- C. Wu, F. Ko, S. Kuo, F. Lee, C. Teng
- Chemistry, Medicine
- British journal of pharmacology
- 1 October 1995
1 Our previous study demonstrated that YC‐1, a derivative of benzylindazole, is a novel activator of soluble guanylate cyclase (sGC) in rabbit platelets. This work investigated whether the… Expand
YC-1 inhibits HIF-1 expression in prostate cancer cells: contribution of Akt/NF-κB signaling to HIF-1α accumulation during hypoxia
Hypoxia-inducible factor 1 (HIF-1), a transcription factor that is critical for tumor adaptation to microenvironmental stimuli, represents an attractive chemotherapeutic target. YC-1 is a novel… Expand
Traditional Chinese medicine herbal extracts of Cibotium barometz, Gentiana scabra, Dioscorea batatas, Cassia tora, and Taxillus chinensis inhibit SARS-CoV replication
- C. Wen, L. Shyur, +6 authors N. Yang
- Biology, Medicine
- Journal of Traditional and Complementary Medicine
- 1 October 2011
Abstract
Development of anti-severe acute respiratory syndrome associated coronavirus (SARS-CoV) agents is pivotal to prevent the reemergence of the life-threatening disease, SARS. In this… Expand
Three new flavonoids and antiallergic, anti-inflammatory constituents from the heartwood of Dalbergia odorifera.
- S. C. Chan, Y. S. Chang, J. Wang, S. C. Chen, S. Kuo
- Medicine, Biology
- Planta medica
- 1 March 1998
Three new flavonoids, (3R)-4'-methoxy-2',3,7-trihydroxyisoflavanone (11), 7-methoxy-3,3',4',6-tetrahydroxyflavone (18), and 2',7-dihydroxy-4',5'-dimethoxyisoflavone (22), were isolated from the… Expand
Metabolism and pharmacokinetics of 3,3',4',7-tetrahydroxyflavone (fisetin), 5-hydroxyflavone, and 7-hydroxyflavone and antihemolysis effects of fisetin and its serum metabolites.
- C. Shia, S. Tsai, S. Kuo, Y. Hou, P. D. Chao
- Chemistry, Medicine
- Journal of agricultural and food chemistry
- 14 January 2009
3,3',4',7-Tetrahydroxyflavone (fisetin) has shown various beneficial bioactivities. This study investigated the metabolism and pharmacokinetics of fisetin, 5-hydroxyflavone (5-OH-flavone), and… Expand
EGFR modulates DNA synthesis and repair through Tyr phosphorylation of histone H4.
Posttranslational modifications of histones play fundamental roles in many biological functions. Specifically, histone H4-K20 methylation is critical for DNA synthesis and repair. However, little is… Expand
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