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YC-1, a novel activator of platelet guanylate cyclase.
TLDR
The data indicate that YC-1 is a direct soluble guanylate cyclase activator in rabbit platelets and may also possess antithrombotic potential in vivo.
YC-1 inhibits HIF-1 expression in prostate cancer cells: contribution of Akt/NF-kappaB signaling to HIF-1alpha accumulation during hypoxia.
TLDR
YC-1 is a novel antitumor agent that inhibits HIF-1 through previously unexplained mechanisms and is found to suppress the PI3K/Akt/mTOR/4E-BP pathway, which serves to regulate Hif-1alpha expression at the translational step.
Enhancement of long-term potentiation by a potent nitric oxide-guanylyl cyclase activator, 3-(5-hydroxymethyl-2-furyl)-1-benzyl-indazole.
TLDR
A novel compound 3-hydroxymethyl-2-furyl-1-benzyl-indazole (YC-1), a drug known to modulate the response of soluble guanylyl cyclase to NO, greatly potentiates long-term potentiation (LTP) in rat hippocampal and amygdala slices by weak tetanic stimulation.
Antioxidant properties of butein isolated from Dalbergia odorifera.
YC‐1 inhibited human platelet aggregation through NO‐independent activation of soluble guanylate cyclase
TLDR
The results would suggest that YC‐1 activates sGC of human platelets by a NO‐independent mechanism, and exerts its antiplatelet effects through the sGC/cyclic GMP pathway.
Three new flavonoids and antiallergic, anti-inflammatory constituents from the heartwood of Dalbergia odorifera.
TLDR
Three new flavonoids isolated from the heartwood of Dalbergia odorifera T. Chen showed significant anti-inflammatory activity and (S)-4-methoxydalbergione and cearoin exhibited antiallergic activity.
YC-1 inhibits HIF-1 expression in prostate cancer cells: contribution of Akt/NF-κB signaling to HIF-1α accumulation during hypoxia
TLDR
YC-1 is a novel antitumor agent that inhibits HIF-1 through previously unexplained mechanisms, and is found to suppress the PI3K/Akt/mTOR/4E-BP pathway, which serves to regulate Hif-1α expression at the translational step.
Metabolism and pharmacokinetics of 3,3',4',7-tetrahydroxyflavone (fisetin), 5-hydroxyflavone, and 7-hydroxyflavone and antihemolysis effects of fisetin and its serum metabolites.
TLDR
Fisetin and 7- OH-flavone were rapidly and extensively biotransformed into their sulfate/glucuronide, whereas 5-OH-Flavone was exclusively metabolized to glucuronide.
Asperjinone, a nor-neolignan, and terrein, a suppressor of ABCG2-expressing breast cancer cells, from thermophilic Aspergillus terreus.
TLDR
Treatment with terrein significantly suppressed growth of ABCG2-expressing breast cancer cells, and this suppressive effect was achieved by inducing apoptosis via activating the caspase-7 pathway and inhibiting the Akt signaling pathway, which led to a decrease in ABCG 2- expressing cells and a reduction in the side-population phenotype.
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