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YC-1, a novel activator of platelet guanylate cyclase.
The data indicate that YC-1 is a direct soluble guanylate cyclase activator in rabbit platelets and may also possess antithrombotic potential in vivo.
YC-1 inhibits HIF-1 expression in prostate cancer cells: contribution of Akt/NF-kappaB signaling to HIF-1alpha accumulation during hypoxia.
YC-1 is a novel antitumor agent that inhibits HIF-1 through previously unexplained mechanisms and is found to suppress the PI3K/Akt/mTOR/4E-BP pathway, which serves to regulate Hif-1alpha expression at the translational step.
Enhancement of long-term potentiation by a potent nitric oxide-guanylyl cyclase activator, 3-(5-hydroxymethyl-2-furyl)-1-benzyl-indazole.
- Wei-Lin Chien, K. Liang, C. Teng, S. Kuo, F. Lee, W. Fu
- Biology, ChemistryMolecular pharmacology
- 1 June 2003
A novel compound 3-hydroxymethyl-2-furyl-1-benzyl-indazole (YC-1), a drug known to modulate the response of soluble guanylyl cyclase to NO, greatly potentiates long-term potentiation (LTP) in rat hippocampal and amygdala slices by weak tetanic stimulation.
Magnolol and honokiol isolated from Magnolia officinalis protect rat heart mitochondria against lipid peroxidation.
Inhibitory effect of YC-1 on the hypoxic induction of erythropoietin and vascular endothelial growth factor in Hep3B cells.
Goniothalamin induces cell cycle-specific apoptosis by modulating the redox status in MDA-MB-231 cells.
Histone Deacetylase Inhibitors Stimulate Histone H3 Lysine 4 Methylation in Part Via Transcriptional Repression of Histone H3 Lysine 4 Demethylases
Evidence indicates that this up-regulation of H3K4 methylation was attributable to the suppressive effect of these HDAC inhibitors on the expression of RBP2 and other JARID1 family histone demethylases, including PLU-1, SMCX, and LSD1, via the down- regulation of Sp1 expression.
Investigation of ouabain-induced anticancer effect in human androgen-independent prostate cancer PC-3 cells.
Antioxidant properties of butein isolated from Dalbergia odorifera.
YC‐1 inhibited human platelet aggregation through NO‐independent activation of soluble guanylate cyclase
- C. Wu, F. Ko, S. Kuo, F. Lee, C. Teng
- Biology, ChemistryBritish journal of pharmacology
- 1 October 1995
The results would suggest that YC‐1 activates sGC of human platelets by a NO‐independent mechanism, and exerts its antiplatelet effects through the sGC/cyclic GMP pathway.