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YC-1, a novel activator of platelet guanylate cyclase.
TLDR
The data indicate that YC-1 is a direct soluble guanylate cyclase activator in rabbit platelets and may also possess antithrombotic potential in vivo. Expand
YC-1 inhibits HIF-1 expression in prostate cancer cells: contribution of Akt/NF-kappaB signaling to HIF-1alpha accumulation during hypoxia.
TLDR
YC-1 is a novel antitumor agent that inhibits HIF-1 through previously unexplained mechanisms and is found to suppress the PI3K/Akt/mTOR/4E-BP pathway, which serves to regulate Hif-1alpha expression at the translational step. Expand
Enhancement of long-term potentiation by a potent nitric oxide-guanylyl cyclase activator, 3-(5-hydroxymethyl-2-furyl)-1-benzyl-indazole.
TLDR
A novel compound 3-hydroxymethyl-2-furyl-1-benzyl-indazole (YC-1), a drug known to modulate the response of soluble guanylyl cyclase to NO, greatly potentiates long-term potentiation (LTP) in rat hippocampal and amygdala slices by weak tetanic stimulation. Expand
Magnolol and honokiol isolated from Magnolia officinalis protect rat heart mitochondria against lipid peroxidation.
TLDR
Both magnolol and honokiol exhibited free radical scavenging activities as shown by the diphenyl-p-picrylhydrazyl assay, but they were less potent than alpha-tocopherol. Expand
Inhibitory effect of YC-1 on the hypoxic induction of erythropoietin and vascular endothelial growth factor in Hep3B cells.
TLDR
The results suggest that YC-1 and SNP suppressed the hypoxia-inducible factor (HIF)-1-mediated hypoxic responses by post-translationally inhibiting HIF-1alpha accumulation. Expand
Investigation of ouabain-induced anticancer effect in human androgen-independent prostate cancer PC-3 cells.
TLDR
It is suggested that ouabain induces two modes of cytotoxic effect in human hormone-independent prostate cancer PC-3 cells using mitochondrial MTT reduction assays and an antisense, but not nonsense, oligomer against Par-4 expression significantly inhibited the cytotoxicity induced by low concentrations of ouABain. Expand
Antioxidant properties of butein isolated from Dalbergia odorifera.
TLDR
It is proposed that butein serves as a powerful antioxidant against lipid and LDL peroxidation by its versatile free radical scavenging actions and metal ion chelation. Expand
YC‐1 inhibited human platelet aggregation through NO‐independent activation of soluble guanylate cyclase
TLDR
The results would suggest that YC‐1 activates sGC of human platelets by a NO‐independent mechanism, and exerts its antiplatelet effects through the sGC/cyclic GMP pathway. Expand
YC-1 inhibits HIF-1 expression in prostate cancer cells: contribution of Akt/NF-κB signaling to HIF-1α accumulation during hypoxia
TLDR
YC-1 is a novel antitumor agent that inhibits HIF-1 through previously unexplained mechanisms, and is found to suppress the PI3K/Akt/mTOR/4E-BP pathway, which serves to regulate Hif-1α expression at the translational step. Expand
Histone Deacetylase Inhibitors Stimulate Histone H3 Lysine 4 Methylation in Part Via Transcriptional Repression of Histone H3 Lysine 4 Demethylases
TLDR
Evidence indicates that this up-regulation of H3K4 methylation was attributable to the suppressive effect of these HDAC inhibitors on the expression of RBP2 and other JARID1 family histone demethylases, including PLU-1, SMCX, and LSD1, via the down- regulation of Sp1 expression. Expand
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