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Pristimerin induces caspase-dependent apoptosis in MDA-MB-231 cells via direct effects on mitochondria
- Chin‐Chung Wu, Mei-Ling Chan, Wen-Ying Chen, Ching-Yi Tsai, F. Chang, Y. Wu
- Biology, ChemistryMolecular Cancer Therapeutics
- 1 August 2005
It is suggested that pristimerin is a novel mitochondria-targeted compound and may be further evaluated as a chemotherapeutic agent for human cancer.
Goniothalamin induces cell cycle-specific apoptosis by modulating the redox status in MDA-MB-231 cells.
Prevention of Platelet Glycoprotein IIb/IIIa Activation by 3,4-Methylenedioxy-β-Nitrostyrene, A Novel Tyrosine Kinase Inhibitor
A small chemical compound, 3,4-methyl-enedioxy-β-nitrostyrene (MNS), exhibited potent and broad-spectrum inhibitory effects on human platelet aggregation caused by various stimulators and may provide a new strategy for treatment of platelet-dependent thrombosis.
The oestrogenic and anti-platelet activities of dihydrobenzofuroisocoumarins and homoisoflavonoids from Liriope platyphylla roots.
New cytotoxic flavonoids from Thelypteris torresiana.
During the search for anti-tumor agents from pteridophytes, three new flavonoids were isolated from Thelypteris torresiana using bioactivity-guided fractionation methods and the structures of the new isolates were elucidated by 1D- and 2D-NMR spectral analysis.
New cytotoxic withanolides from Physalis peruviana
New ent-kaurane diterpenoids with anti-platelet aggregation activity from Annona squamosa.
- Yu-Liang Yang, F. Chang, Chin‐Chung Wu, Wei-Ya Wang, Y. Wu
- ChemistryJournal of natural products
- 1 October 2002
Compound 1 is the first dimeric ent-kaurane derivative to have been reported from a plant in the family Annonaceae and showed complete inhibitory effects on rabbit platelet aggregation at 200 microM.
The role of PAR4 in thrombin-induced thromboxane production in human platelets.
- Chin‐Chung Wu, T. Hwang, C. Liao, S. Kuo, F. Lee, C. Teng
- Biology, ChemistryThrombosis and haemostasis
- 11 July 2003
The results suggest that PAR4 plays an important role in the regulation of thromboxane formation in platelets responding to thrombin through prolonged elevation of [Ca(2+)](i) and activation of phospholipase A(2).
New cytotoxic 6-oxygenated 8,9-dihydrofurocoumarins, hedyotiscone A - C, from Hedyotis biflora.
Using the bioactivity-guided fractionation method, three new 6-oxygenated 8,9-dihydrofurocoumarin-type compounds, hedyotiscones A, B, and C were isolated from the methanol extract of Hedyotis biflora…
Tubocapsenolide A, a Novel Withanolide, Inhibits Proliferation and Induces Apoptosis in MDA-MB-231 Cells by Thiol Oxidation of Heat Shock Proteins*
- W. Y. Chen, F. Chang, Zih-You Huang, Jyun-Hong Chen, Y. Wu, Chin‐Chung Wu
- Biology, ChemistryJournal of Biological Chemistry
- 20 June 2008
Results demonstrate that the TA inhibits the activity of Hsp90-Hsp70 chaperone complex, at least in part, by a direct thiol oxidation, which in turn leads to the destabilization and depletion of HSp90 client proteins and thus causes cell cycle arrest and apoptosis in MDA-MB-231 cells.