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Pristimerin induces caspase-dependent apoptosis in MDA-MB-231 cells via direct effects on mitochondria
TLDR
It is suggested that pristimerin is a novel mitochondria-targeted compound and may be further evaluated as a chemotherapeutic agent for human cancer.
Prevention of Platelet Glycoprotein IIb/IIIa Activation by 3,4-Methylenedioxy-β-Nitrostyrene, A Novel Tyrosine Kinase Inhibitor
TLDR
A small chemical compound, 3,4-methyl-enedioxy-β-nitrostyrene (MNS), exhibited potent and broad-spectrum inhibitory effects on human platelet aggregation caused by various stimulators and may provide a new strategy for treatment of platelet-dependent thrombosis.
New cytotoxic flavonoids from Thelypteris torresiana.
TLDR
During the search for anti-tumor agents from pteridophytes, three new flavonoids were isolated from Thelypteris torresiana using bioactivity-guided fractionation methods and the structures of the new isolates were elucidated by 1D- and 2D-NMR spectral analysis.
New ent-kaurane diterpenoids with anti-platelet aggregation activity from Annona squamosa.
TLDR
Compound 1 is the first dimeric ent-kaurane derivative to have been reported from a plant in the family Annonaceae and showed complete inhibitory effects on rabbit platelet aggregation at 200 microM.
The role of PAR4 in thrombin-induced thromboxane production in human platelets.
TLDR
The results suggest that PAR4 plays an important role in the regulation of thromboxane formation in platelets responding to thrombin through prolonged elevation of [Ca(2+)](i) and activation of phospholipase A(2).
New cytotoxic 6-oxygenated 8,9-dihydrofurocoumarins, hedyotiscone A - C, from Hedyotis biflora.
Using the bioactivity-guided fractionation method, three new 6-oxygenated 8,9-dihydrofurocoumarin-type compounds, hedyotiscones A, B, and C were isolated from the methanol extract of Hedyotis biflora
Tubocapsenolide A, a Novel Withanolide, Inhibits Proliferation and Induces Apoptosis in MDA-MB-231 Cells by Thiol Oxidation of Heat Shock Proteins*
TLDR
Results demonstrate that the TA inhibits the activity of Hsp90-Hsp70 chaperone complex, at least in part, by a direct thiol oxidation, which in turn leads to the destabilization and depletion of HSp90 client proteins and thus causes cell cycle arrest and apoptosis in MDA-MB-231 cells.
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