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Direct activation of human TRPC6 and TRPC3 channels by diacylglycerol
TLDR
The molecular mechanism of store-depletion-independent activation of a subfamily of mammalian TRPC channels is described and it is found that hTRPC6 is a non-selective cation channel that is activated by diacylglycerol in a membrane-delimited fashion, independently of protein kinases C activated bydiacyl Glycerol. Expand
Receptor-mediated Regulation of the Nonselective Cation Channels TRPC4 and TRPC5*
TLDR
mTRPC4 and mTRPC5 form nonselective cation channels that integrate signaling pathways from G-protein-coupled receptors and receptor tyrosine kinases independently of store depletion, which is inconsistent with those ofI CRAC, the most extensively characterized store-operated current. Expand
Subunit composition of mammalian transient receptor potential channels in living cells
TLDR
This work investigates the combinatorial rules of TRPC assembly by pursuing four independent experimental approaches and shows that TRPC2 does not interact with any known TRPC protein andTRPC1 has the ability to form channel complexes together with TRPC4 and TRPC5. Expand
OTRPC4, a nonselective cation channel that confers sensitivity to extracellular osmolarity
TLDR
A new TRP (transient receptor potential)-like channel protein, OTRPC4, that is expressed at high levels in the kidney, liver and heart is identified and proposed as a candidate for a molecular sensor that confers osmosensitivity on mammalian cells. Expand
Lanthanides Potentiate TRPC5 Currents by an Action at Extracellular Sites Close to the Pore Mouth*
TLDR
It is concluded that in the micromolar range, the lanthanide ions La3+ and Gd3+ have opposite effects on whole cell currents through TRPC5 and TRPC6 channels. Expand
International Union of Pharmacology. XLIX. Nomenclature and Structure-Function Relationships of Transient Receptor Potential Channels
TLDR
At present, no features, other than overall 6TM architecture/homology and cationic permeability, define the TRP family, and the definition of TRP channels will evolve as functions and structures are clarified. Expand
A unified nomenclature for the superfamily of TRP cation channels.
TLDR
The current effort to unify the TRP nomenclature focuses on three subfamilies that bear significant similarities to the founding member of this superfamily, Drosophila TRP, and which include highly related members in worms, flies, mice, and humans. Expand
Molecular and Functional Characterization of the Melastatin-related Cation Channel TRPM3*
TLDR
From its function and expression in human kidney, a role of TRPM3 is proposed in renal Ca2+ homeostasis, suggesting volume-regulated activity of TRP3. Expand
Cloning and Functional Expression of a Human Ca2+-Permeable Cation Channel Activated by Calcium Store Depletion
TLDR
It is concluded that TRPC1A encodes a Ca2+-permeable cation channel activated by depletion of intracellular calcium stores. Expand
Homo- and heteromeric assembly of TRPV channel subunits
TLDR
The homo- and heteromultimerization of TRPV channel subunits revealed that the specificity and the affinity of the subunit interaction is synergistically provided by interaction modules located in the transmembrane domains and in the cytosolic termini. Expand
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