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tariquidar

Known as: tariquidarth 
An anthranilamide derivative with multidrug resistance properties. Tariquidar non-competitively binds to the p-glycoprotein transporter, thereby… 
National Institutes of Health

Related topics

Related topics

4 relations
NCIt Antineoplastic Agent Terminologytariquidar/vinorelbine

Broader (1)

Quinolines

Narrower (1)

XR9576

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2017
2017
The reversal of multidrug resistance in ovarian carcinoma cells by co-application of tariquidar and paclitaxel in transferrin-targeted polymeric micelles
Abstract In this study, a transferrin (Tf)-modified polyethylene glycol-phosphatidyl ethanolamine (PEG-PE)-based micellar… 
2017
2017
ABC transporters in the liver fluke Opisthorchis felineus.
2016
2016
Increasing nerve agent treatment efficacy by P-glycoprotein inhibition.
2013
2013
Interactions of the Multidrug Resistance Modulators Tariquidar and Elacridar and their Analogues with P‐glycoprotein
Tariquidar and elacridar are among the most potent inhibitors of the multidrug resistance transporter P‐glycoprotein (P‐gp), but… 
2010
2010
Exposure to antiepileptic drugs does not alter the functionality of P-glycoprotein in brain capillary endothelial and kidney cell lines.
Highly Cited
2008
Highly Cited
2008
Effect of the ABCB1 modulators elacridar and tariquidar on the distribution of paclitaxel in nude mice
PurposePreviously, we studied the effect of co-administration of paclitaxel with the second generation ABCB1 (p-gp) modulator… 
Highly Cited
2008
Highly Cited
2008
Glutamate is critically involved in seizure-induced overexpression of P-glycoprotein in the brain
Highly Cited
2006
Highly Cited
2006
Determinants of drug brain uptake in a rat model of seizure-associated malformations of cortical development
2004
2004
Ex vivo reversal of chemoresistance by tariquidar (XR9576)
The expression of P-glycoprotein (P-gp) has been demonstrated to confer resistance to several anticancer drugs, including… 
Highly Cited
2003
Highly Cited
2003
Increased 99mTc-sestamibi accumulation in normal liver and drug-resistant tumors after the administration of the glycoprotein inhibitor, XR9576.
99mTc-sestamibi, a substrate of the multidrug transporter P-glycoprotein (Pgp), has been used as a functional imaging agent for… 
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