tariquidar

Known as: tariquidarth 
An anthranilamide derivative with multidrug resistance properties. Tariquidar non-competitively binds to the p-glycoprotein transporter, thereby… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

2003-2017
0102020032017

Papers overview

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2012
2012
Using positron emission tomography (PET) imaging we assessed, in vivo, the interaction between a microdose of (R)-[(11)C… (More)
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2011
2011
One of the major obstacles to the success of cancer chemotherapy is the multidrug resistance (MDR) often resulting due to the… (More)
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2011
2011
Tariquidar was developed as a specific inhibitor of the efflux transporter ABCB1. Recent positron emission tomographic brain… (More)
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Highly Cited
2009
Highly Cited
2009
Drug resistance is a major obstacle to the success of cancer chemotherapy. Overexpression of the drug-efflux transporter P… (More)
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2009
2009
PURPOSE P-glycoprotein (Pgp) antagonists have had unpredictable pharmacokinetic interactions requiring reductions of chemotherapy… (More)
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Highly Cited
2008
Highly Cited
2008
Whereas target-specific drugs are available for treating ERBB2-overexpressing and hormone receptor-positive breast cancers, no… (More)
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Highly Cited
2008
Highly Cited
2008
One of the current hypotheses of pharmacoresistant epilepsy proposes that transport of antiepileptic drugs (AEDs) by drug efflux… (More)
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2007
2007
Previously, we studied the effect of co-administration of paclitaxel with the second generation ABCB1 (p-gp) modulator valspodar… (More)
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Highly Cited
2005
Highly Cited
2005
BACKGROUND The primary objective of this study was to determine whether addition of the selective P-glycoprotein (P-gp) inhibitor… (More)
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Highly Cited
2004
Highly Cited
2004
Pheophorbide a (PhA), a chlorophyll catabolite, was shown to be an ABCG2 substrate based on Abcg2(-/-) knockout mouse studies (J… (More)
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