• Publications
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Locality Sensitive Deep Learning for Detection and Classification of Nuclei in Routine Colon Cancer Histology Images
A Spatially Constrained Convolutional Neural Network (SC-CNN) to perform nucleus detection and a novel Neighboring Ensemble Predictor (NEP) coupled with CNN to more accurately predict the class label of detected cell nuclei are proposed. Expand
Chemosensitivity testing of human tumors using a microplate adenosine triphosphate luminescence assay: clinical correlation for cisplatin resistance of ovarian carcinoma.
An ATP luminescence assay (TCA 100) was used to measure chemotherapeutic drug sensitivity and resistance of dissociated tumor cells cultured for 6 days in serum-free medium and 96-well polypropylene microplates and indicates that the assay has > 90% accuracy for cisplatin resistance of ovarian carcinoma. Expand
Histological features of ocular adnexal lymphoma (REAL classification) and their association with patient morbidity and survival
Patients with ocular adnexal lymphoma can be classified by REAL into five distinct groups, which show a progressive increase in the risks of extraorbital disease at diagnosis, of disease dissemination with time, and of tumour related death. Expand
Clinical features associated with survival of patients with lymphoma of the ocular adnexa
It is suggested that presenting symptoms and signs of patients with ocular adnexal lymphoma are significantly associated with the risk of systemic disease at orbital presentation, the rate of subsequent spread, and the rates of lymphoma-related death. Expand
A common classification framework for neuroendocrine neoplasms: an International Agency for Research on Cancer (IARC) and World Health Organization (WHO) expert consensus proposal
This work believes this conceptual approach can form the basis for the next generation of NEN classifications and will allow more consistent taxonomy to understand how neoplasms from different organ systems inter-relate clinically and genetically. Expand
Comparison of MTT and ATP-based assays for the measurement of viable cell number.
The ATP assay showed better reproducibility and sensitivity when cells were grown in microtitre plates over several days, and is particularly useful for the measurement of viability with low cell numbers. Expand
The 2019 WHO classification of tumours of the digestive system
For the first time, certain tumour types are defined as much by their molecular phenotype as their histological characteristics; however, histopathological classification remains the gold standard for diagnosis in most instances. Expand
Toxicity of natural tear substitutes in a fully defined culture model of human corneal epithelial cells.
Isotonic saliva and serum offer greater therapeutic potential for severely aqueous-deficient dry eyes than do pharmaceutical tear substitutes and Cellular ATP is a sensitive parameter for quantifying toxicity. Expand
The 2019 World Health Organization classification of tumours of the breast
  • Puay Hoon Tan, I. Ellis, +15 authors I. Cree
  • Medicine
  • Histopathology
  • 13 February 2020
The newly published World Health Organization (WHO) Classification of Tumours of the breast features significant changes compared to earlier editions. In this review, we outline the major changes inExpand