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XR9576

Known as: XR 9576 
National Institutes of Health

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1 relation

Broader (1)

tariquidar

Papers overview

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2011
2011
Synthesis and in vivo evaluation of ¹⁸F-fluoroethyl GF120918 and XR9576 as positron emission tomography probes for assessing the function of drug efflux transporters.
2010
2010
Synthesis and evaluation of [11C]XR9576 to assess the function of drug efflux transporters using PET
ObjectiveXR9576 (tariquidar) is an anthranilic acid derivative and potent P-glycoprotein (P-gp) inhibitor. XR9576 has undergone… 
2010
2010
Abstract 3527: A pharmacodynamic study of docetaxel in combination with the p-glycoprotein antagonist, tariquidar (XR9576) in patients with lung, ovarian, and cervical cancer
Purpose: P-glycoprotein (Pgp) antagonists have been difficult to develop because of complex pharmacokinetic interactions and a… 
2010
2010
Analysis of P-glycoprotein structure and binding sites
Multidrug resistance is one of the major causes for the failure to successful chemotherapy. Although there are many mechanisms… 
2006
2006
In vitro activity of novel dual action MDR anthranilamide modulators with inhibitory activity on CYP-450 (Part 2).
2006
2006
In vitro activity of novel dual action MDR anthranilamide modulators with inhibitory activity at CYP-450.
Synthesis and in vitro cytotoxicity assays of new anthranilamide MDR modulators have been performed to assess their inhibition… 
2003
2003
Optimizing chemotherapy by measuring reversal of P-glycoprotein activity in plasma membrane vesicles.
The appearance of multidrug resistance (MDR) of cancer cells is a major obstacle to successful chemotherapy. Several proteins… 
Highly Cited
2003
Highly Cited
2003
Pumping of Drugs by P-Glycoprotein: A Two-Step Process?
The apparent inhibition constant, Kapp, for the blockade of P-glycoprotein (P-gp) by four drugs, verapamil, cyclosporin A, XR9576… 
2003
2003
JPET # 56960 Page 2 RUNNING TITLE PAGE Running title : Two-step pumping by P-glycoprotein
The apparent inhibition constant, Kapp, for the blockade of P-glycoprotein (P-gp) by four drugs, verapamil, cyclosporin A, XR9576… 
2001
2001
In Vitro and in Vivo Reversal of P-Glycoprotein-mediated Multidrug Resistance by a Novel Potent Modulator , XR 9576
  • 2001
  • Corpus ID: 21453389
The overexpression of P-glycoprotein (P-gp) on the surface of tumor cells causes multidrug resistance (MDR). This protein acts as… 
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