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XR9576

Known as: XR 9576 
 
National Institutes of Health

Papers overview

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Highly Cited
2011
Highly Cited
2011
One of the major obstacles to the success of cancer chemotherapy is the multidrug resistance (MDR) often resulting due to the… Expand
Highly Cited
2010
Highly Cited
2010
Purpose: P-glycoprotein (Pgp) antagonists have been difficult to develop because of complex pharmacokinetic interactions and a… Expand
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2010
2010
ObjectiveXR9576 (tariquidar) is an anthranilic acid derivative and potent P-glycoprotein (P-gp) inhibitor. XR9576 has undergone… Expand
Highly Cited
2009
Highly Cited
2009
Purpose: P-glycoprotein (Pgp) antagonists have had unpredictable pharmacokinetic interactions requiring reductions of… Expand
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2009
2009
The development of new modulators possessing high efficacy, low toxicity and high selectivity is a pivotal approach to overcoming… Expand
Highly Cited
2007
Highly Cited
2007
Summary:  Purpose: A biotechnologic breakthrough for the study of drug permeability across the blood–brain barrier (BBB) would be… Expand
Highly Cited
2003
Highly Cited
2003
99mTc-sestamibi, a substrate of the multidrug transporter P-glycoprotein (Pgp), has been used as a functional imaging agent for… Expand
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2003
2003
Paclitaxel (Taxol) is a clinically important chemotherapeutic agent. We describe the synthesis of fluoro-, bromo-, and… Expand
Highly Cited
2001
Highly Cited
2001
The overexpression of P-glycoprotein (P-gp) on the surface of tumor cells causes multidrug resistance (MDR). This protein acts as… Expand
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Highly Cited
2000
Highly Cited
2000
XR9576 is a novel inhibitor of P-glycoprotein (P-gp) that has been shown to reverse P-gp-dependent multidrug-resistance in tumor… Expand
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