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Schizophrenia is associated with elevated amphetamine-induced synaptic dopamine concentrations: evidence from a novel positron emission tomography method.
  • A. Breier, T. Su, +8 authors D. Pickar
  • Chemistry, Medicine
  • Proceedings of the National Academy of Sciences…
  • 18 March 1997
A major line of evidence that supports the hypothesis of dopamine overactivity in schizophrenia is the psychomimetic potential of agents such as amphetamine that stimulate dopamine outflow. A novelExpand
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Kinetic Modeling of [11C]Raclopride: Combined PET-Microdialysis Studies
The in vivo binding of D2 receptor ligands can be affected by agents that alter the concentration of endogenous dopamine. To define a more explicit relation between dopamine and D2 receptor binding,Expand
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Measurement of dopamine release with continuous infusion of [11C]raclopride: optimization and signal-to-noise considerations.
UNLABELLED PET studies with [11C]raclopride provide an indirect measure of changes in synaptic dopamine. Previously, we used the bolus-plus-infusion (B/I) method to assess dopamine response from theExpand
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Quantification of Amphetamine-Induced Changes in [11C]Raclopride Binding with Continuous Infusion
Positron emission tomography and single-photon emission computer tomography receptor-binding ligands can be used to measure changes in neurotransmitter levels. In particular, amphetamine-inducedExpand
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5-HT 1A receptors are reduced in temporal lobe epilepsy after partial-volume correction.
UNLABELLED Preclinical studies suggest that serotonin 1A receptors (5-HT 1A) play a role in temporal lobe epilepsy (TLE). Previous PET studies reported decreased 5-HT 1A binding ipsilateral toExpand
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Reduced Serotonin Type 1A Receptor Binding in Panic Disorder
Recent animal models suggest that disturbances in serotonin type-1A receptor (5-HT1AR) function may contribute to chronic anxiety, although it is not clear at all whether such models constituteExpand
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99mTc-Labeled Small-Molecule Inhibitors of Prostate-Specific Membrane Antigen for Molecular Imaging of Prostate Cancer
Prostate-specific membrane antigen (PSMA) is highly expressed in prostate cancer, and small-molecule radiopharmaceuticals targeting PSMA rapidly detect the location and extent of disease. Here weExpand
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Brain Uptake of the Acid Metabolites of F-18—Labeled WAY 100635 Analogs
The 5-HT1A ligands [F]FPWAY and [18F]FCWAY are metabolized in vivo to [18F]fluorobenzoic acid (FB) and [18F]fluorocyclohexanecarboxylic acid (FC), respectively. To quantify the penetration of theseExpand
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Molecular targets.
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The Progress and Promise of Molecular Imaging Probes in Oncologic Drug Development
As addressed by the recent Food and Drug Administration Critical Path Initiative, tools are urgently needed to increase the speed, efficiency, and cost-effectiveness of drug development for cancerExpand
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