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taltobulin
An analogue of the naturally occurring tripeptide hemiasterlin, with potential antimitotic and antineoplastic activities. Taltobulin binds tubulin in…
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National Institutes of Health
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2 relations
HTI-286
Microtubule Process
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2019
2019
Conceptual DFT as a chemoinformatics tool for the study of the Taltobulin anticancer peptide
N. Flores-Holguín
,
J. Frau
,
D. Glossman‐Mitnik
BMC Research Notes
2019
Corpus ID: 198132800
A well-behaved model chemistry previously validated for the study of the chemical reactivity of peptides was considered for the…
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Review
2017
Review
2017
Sponging off nature for new drug leads.
R. Andersen
Biochemical Pharmacology
2017
Corpus ID: 5075295
2016
2016
Structural Insights into the Pharmacophore of Vinca Domain Inhibitors of Microtubules s
Yuxi Wang
,
F. Benz
,
+7 authors
Jinliang Yang
2016
Corpus ID: 36734138
Antibody-drug conjugates (ADCs) have achieved great success in cancer therapy in recent years. Some peptidyl microtubule…
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2011
2011
The Dolastatins: Novel Antitumor Agents from Dolabella auricularia
G. Cragg
,
D. Kingston
,
D. Newman
2011
Corpus ID: 220769229
2010
2010
Absolute configurations of tubulin inhibitors taltobulin (HTI-286) and HTI-042 characterized by X-ray diffraction analysis and NMR studies.
C. Niu
,
D. Ho
,
R. Williamson
,
A. Zask
,
S. Ayral-Kaloustian
Bioorganic & Medicinal Chemistry Letters
2010
Corpus ID: 45037878
2006
2006
Mapping the bound conformation and protein interactions of microtubule destabilizing peptides by STD-NMR spectroscopy.
M. J. Milton
,
R. Thomas Williamson
,
F. Koehn
Bioorganic & Medicinal Chemistry Letters
2006
Corpus ID: 8480965
2006
2006
Inhibition of hepatic tumor cell proliferation in vitro and tumor growth in vivo by taltobulin, a synthetic analogue of the tripeptide hemiasterlin.
Y. Vashist
,
C. Tiffon
,
C. Stoupis
,
C. Redaelli
World Journal of Gastroenterology
2006
Corpus ID: 13279971
AIM To investigate the inhibitory effects of taltobulin (HTI-286), a synthetic analogue of natural hemiasterlin derived from…
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2005
2005
Hybrids of the hemiasterlin analogue taltobulin and the dolastatins are potent antimicrotubule agents.
A. Zask
,
Joshua A Kaplan
,
S. Musto
,
F. Loganzo
Journal of the American Chemical Society
2005
Corpus ID: 22835068
The targeting of microtubules is an important mechanism for cancer chemotherapy. However, there is still a need for improved…
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2005
2005
Taltobulin : Oncolytic drug Prop INN tubulin polymerization inhibitor antimitotic drug
S. Ayral-Kaloustian
,
A. Zask
2005
Corpus ID: 88764308
Antimicrotubule agents are among the most effective drugs for the treatment of breast, ovarian and other forms of cancer. Two…
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2004
2004
Gateways to clinical trials.
M. Bayés
,
X. Rabasseda
,
J. Prous
Methods and Findings in Experimental and Clinical…
2004
Corpus ID: 19668842
Gateways to Clinical Trials is a guide to the most recent clinical trials in current literature and congresses. The data in the…
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