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Research on adverse drug events. I. Muscarinic M3 receptor binding affinity could predict the risk of antipsychotics to induce type 2 diabetes.
TLDR
This study provides the first direct evidence to indicate that antipsychotic agents with high binding affinity to the muscarinic M3 receptor are associated with an elevated risk for type 2 diabetes. Expand
Clinical pharmacokinetics of statins.
TLDR
All statins with the exception of pitavastatin show very low systemic bioavailability due to an extensive first pass effect at the intestinal and/or hepatic level, and pravastatin has the lowest protein binding and shows the longest terminal half-life. Expand
Preclinical pharmacokinetics of statins.
TLDR
This review summarizes the pharmacokinetic properties of HMG-CoA reductase inhibitors (or statins) reported in animals and concludes that the highest tissue levels are found in the liver--the target organ. Expand
Gateways to clinical trials.
TLDR
This issue focuses on the following selection of drugs: (Z)-4-Hydroxytamoxifen, [18F]-FPS, and the most recent clinical trials in current literature and congresses. Expand
Gateways to clinical trials.
TLDR
This issue focuses on the following selection of drugs: 101M. Expand
Pharmacological treatment of Alzheimer disease: from psychotropic drugs and cholinesterase inhibitors to pharmacogenomics.
TLDR
The pharmacological treatment of AD should rely on a better understanding of AD etiopathogenesis in order to use current drugs that protect the AD brain against deleterious events and to develop new drugs specifically designed to inhibit and/or regulate those factors responsible for premature neuronal death in AD. Expand
Comparative evaluation of hERG potassium channel blockade by antipsychotics.
Blockade of human ether-a-go-go-related gene (hERG) potassium channels is an undesirable activity of many drugs because it may be the primary cause for the prolongation of the QT interval, whichExpand
Gateways to clinical trials. March 2003.
Gateways to clinical Trials is a guide to the most recent clinical trials in current literature and congresses. The data in the following tables has been retrieved from the Clinical Studies knowledgeExpand
Pharmacokinetic interactions of statins.
TLDR
Patients treated with other drugs that have the potential ability to interact with statins should be monitored and modification of the total HMG-CoA inhibitors instead of just the parent drug profile is to be considered when evaluating the clinical relevance of the interaction. Expand
Gateways to clinical trials.
TLDR
This issue focuses on the following selection of drugs: flurbiprofen, 90Yttrium-DOTA-huJ591, human papillomavirus vaccine, and parathyroid hormone. Expand
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