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HTI-286

Known as: HTI 286, HTI286 
National Institutes of Health

Related topics

Related topics

3 relations

Broader (1)

Oligopeptides
SPA110taltobulin

Papers overview

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Review
2017
Review
2017
Sponging off nature for new drug leads.
2011
2011
The Dolastatins: Novel Antitumor Agents from Dolabella auricularia
2008
2008
Intravesical Chemotherapy of High-Grade Bladder Cancer with HTI-286, A Synthetic Analogue of the Marine Sponge Product Hemiasterlin
Purpose: HTI-286 is a fully synthetic analogue of the natural tripeptide hemiasterlin that inhibits tubulin polymerization and… 
2008
2008
Tubulysin analogs incorporating desmethyl and dimethyl tubuphenylalanine derivatives.
2006
2006
Mapping the bound conformation and protein interactions of microtubule destabilizing peptides by STD-NMR spectroscopy.
2004
2004
Cells resistant to HTI-286 do not overexpress P-glycoprotein but have reduced drug accumulation and a point mutation in alpha-tubulin.
HTI-286, a synthetic analogue of hemiasterlin, depolymerizes microtubules and is proposed to bind at the Vinca peptide site in… 
2004
2004
Synthesis and activity of novel analogs of hemiasterlin as inhibitors of tubulin polymerization: modification of the A segment.
2004
2004
Tumor cells resistant to a microtubule-depolymerizing hemiasterlin analogue, HTI-286, have mutations in alpha- or beta-tubulin and increased microtubule stability.
Hemiasterlins are sponge-derived tripeptides that inhibit cell growth by depolymerizing existing microtubules and inhibiting… 
Highly Cited
2003
Highly Cited
2003
HTI-286, a synthetic analogue of the tripeptide hemiasterlin, is a potent antimicrotubule agent that circumvents P-glycoprotein-mediated resistance in vitro and in vivo.
Hemiasterlin is a natural product derived from marine sponges that, like other structurally diverse peptide-like molecules, binds… 
2003
2003
Biophysical characterization of the interactions of HTI-286 with tubulin heterodimer and microtubules.
HTI-286 is a synthetic analogue of the natural product hemiasterlin and is a potent antimitotic agent. HTI-286 inhibits the… 
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