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Raf-1/bcl-2 phosphorylation: a step from microtubule damage to cell death.
TLDR
It is demonstrated that, in addition to paclitaxel, other agents that interact with tubulin and microtubules also induce Raf-1/bcl-2 phosphorylation, whereas DNA-damaging drugs, antimetabolites, and alkylating agents do not. Expand
Anticancer Agents from Natural Products
Introduction Gordon M. Cragg, David G. I. Kingston, and David J. Newman Camptothecin and Its Analogs Nicolas J. Rahier, Craig J. Thomas, and Sidney M. Hecht The Discovery and Development of theExpand
Modern natural products drug discovery and its relevance to biodiversity conservation.
  • D. Kingston
  • Business, Medicine
  • Journal of natural products
  • 25 March 2011
TLDR
Results from International Cooperative Biodiversity Groups working in Madagascar, Panama, and Suriname are used as examples of what can be achieved when biodiversity conservation is linked to drug discovery. Expand
Tubulin-interactive natural products as anticancer agents.
  • D. Kingston
  • Chemistry, Medicine
  • Journal of natural products
  • 6 January 2009
TLDR
The vinca alkaloids, the combretastatins, NPI-2358, the halichondrin B analogue eribulin, dolastatin 10, noscapine, hemiasterlin, and rhizoxin are discussed as tubulin polymerization inhibitors, while the taxanes and the epothilones are the major classes of tubulin polymers presented. Expand
Colloidal gold nanoparticles: a novel nanoparticle platform for developing multifunctional tumor‐targeted drug delivery vectors
TLDR
This work discusses the development of colloidal gold‐based drugs that are designed to target the delivery of TNF and paclitaxel to solid tumors and attempts to build such multifunctional nanotherapeutics using colloidalgold nanoparticles. Expand
Bioactive iridoids and a new lignan from Allamanda cathartica and Himatanthus fallax from the Suriname rainforest.
Bioassay-guided fractionation of the EtOAc extract of both Allamanda cathartica and Himatanthus fallax (Apocynaceae) using the Sc-7 yeast strain resulted in the isolation of the weakly cytotoxicExpand
The chemistry of taxol.
  • D. Kingston
  • Chemistry, Medicine
  • Pharmacology & therapeutics
  • 1 October 1991
Abstract The chemistry of the potent anticancer diterpenoid taxol is reviewed, with an emphasis on isolation and analysis, structural modifications, partial synthesis, and structure-activityExpand
Kaurane and trachylobane diterpenes from Xylopia aethiopica
Abstract Phytochemical investigation of Xylopia aethiopica (Annonaceae) has resulted in the isolation of two novel diterpenes, 15-oxo-(-)-trachyloban-19-oic acid and (-)-kaur-15-en-17-al-19-oic acid.Expand
Small molecule schweinfurthins selectively inhibit cancer cell proliferation and mTOR/AKT signaling by interfering with trans-Golgi-network trafficking
TLDR
A previously unrecognized role of schweinfurthins in regulating trans-Golgi-network trafficking is revealed and this cellular effect with mTOR/AKT signaling and with cancer cell survival and growth is linked. Expand
Acetylated DNA-damaging clerodane diterpenes from Casearia sylvestris.
TLDR
The diterpenes 1-3 exhibited moderate but selective activity towards the DNA-repair deficient yeast Saccharomyces cerevisiae mutants RAD 52YK and RS 321. Expand
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