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Anticancer Agents from Natural Products
This work focuses on the discovery and development of novel Antitumor Agents from Dolabella auricularia, as well as the evaluation of (+)-CC-1065 Analogs and Conjugates with Polyamides and their applications in Anticancer Natural Products.
Raf-1/bcl-2 phosphorylation: a step from microtubule damage to cell death.
It is demonstrated that, in addition to paclitaxel, other agents that interact with tubulin and microtubules also induce Raf-1/bcl-2 phosphorylation, whereas DNA-damaging drugs, antimetabolites, and alkylating agents do not.
Modern natural products drug discovery and its relevance to biodiversity conservation.
- D. Kingston
- Environmental Science, BiologyJournal of Natural Products
- 25 March 2011
Results from International Cooperative Biodiversity Groups working in Madagascar, Panama, and Suriname are used as examples of what can be achieved when biodiversity conservation is linked to drug discovery.
Tubulin-interactive natural products as anticancer agents.
- D. Kingston
- Biology, ChemistryJournal of Natural Products
- 12 April 2008
The vinca alkaloids, the combretastatins, NPI-2358, the halichondrin B analogue eribulin, dolastatin 10, noscapine, hemiasterlin, and rhizoxin are discussed as tubulin polymerization inhibitors, while the taxanes and the epothilones are the major classes of tubulin polymers presented.
Colloidal gold nanoparticles: a novel nanoparticle platform for developing multifunctional tumor‐targeted drug delivery vectors
This work discusses the development of colloidal gold‐based drugs that are designed to target the delivery of TNF and paclitaxel to solid tumors and attempts to build such multifunctional nanotherapeutics using colloidalgold nanoparticles.
Bioactive iridoids and a new lignan from Allamanda cathartica and Himatanthus fallax from the Suriname rainforest.
- M. Abdel-Kader, J. Wisse, R. Evans, H. VAN DER WERFF, D. Kingston
- BiologyJournal of natural products
- 22 December 1997
Bioassay-guided fractionation of the EtOAc extract of both Allamanda cathartica and Himatanthus fallax (Apocynaceae) using the Sc-7 yeast strain resulted in the isolation of the weakly cytotoxic…
The taxane diterpenoids.
- D. Kingston, A. A. Molinero, J. Rimoldi
- ChemistryFortschritte der Chemie organischer Naturstoffe…
- 8 November 1994
The structures of over 350 taxane diterpenoids are classified and presented with information on their plant source, yield, melting point, and optical activity. The biotransformations and biosynthesis…
The chemistry of taxol.
- D. Kingston
- ChemistryPharmacology & therapeutics
- 1 October 1991
Cytotoxic triterpenoid saponins of Albizia gummifera from the Madagascar rain forest.
Three new cytotoxic oleanane-type triterpenoid saponins, gummiferaosides A-C, showed cytotoxicity against the A2780 human ovarian cancer cell line with IC50 values of 0.8, 1.5, and 0.6 microg/mL, respectively.