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Natural products as sources of new drugs over the last 25 years.
This review is an updated and expanded version of two prior reviews that were published in this journal in 1997 and 2003. In the case of all approved agents the time frame has been extended to… Expand
Natural products as sources of new drugs over the period 1981-2002.
This review is an updated and expanded version of a paper that was published in this journal in 1997. The time frame has been extended in both directions to include the 22 years from 1981 to 2002,… Expand
Natural products as sources of new drugs over the 30 years from 1981 to 2010.
This review is an updated and expanded version of the three prior reviews that were published in this journal in 1997, 2003, and 2007. In the case of all approved therapeutic agents, the time frame… Expand
Natural products: a continuing source of novel drug leads.
BACKGROUND Nature has been a source of medicinal products for millennia, with many useful drugs developed from plant sources. Following discovery of the penicillins, drug discovery from microbial… Expand
Plants as a source of anti-cancer agents.
Plant-derived compounds have been an important source of several clinically useful anti-cancer agents. These include vinblastine, vincristine, the camptothecin derivatives, topotecan and irinotecan,… Expand
The influence of natural products upon drug discovery.
Natural products in drug discovery and development.
Natural Products as Sources of New Drugs from 1981 to 2014.
This contribution is a completely updated and expanded version of the four prior analogous reviews that were published in this journal in 1997, 2003, 2007, and 2012. In the case of all approved… Expand
Serum cystatin C measured by automated immunoassay: a more sensitive marker of changes in GFR than serum creatinine.
Serum cystatin C has been suggested as a new marker of GFR. For the introduction of this marker into clinical use a rapid and automated method is required. We have developed and validated an assay… Expand
The odyssey of marine pharmaceuticals: a current pipeline perspective.
The global marine pharmaceutical pipeline consists of three Food and Drug Administration (FDA) approved drugs, one EU registered drug, 13 natural products (or derivatives thereof) in different phases… Expand