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tallimustine

Known as: 1H-Pyrrole-2-carboxamide, N-(5-(((3-amino-3-iminopropyl)amino)carbonyl)-1-methyl-1H-pyrrol-3-yl)-4-(((4-((4-(bis(2-chloroethyl)amino)benzoyl)amino)-1-methyl-1H-pyrrol-2-yl)carbonyl)amino)-1-methyl-, N-deformyl-N-(4-N-N,N-bis(2-choroethylamino)benzoyl)distamycin 
A benzoyl mustard derivative of the antiviral agent distamycin A with potential antineoplastic activity. Tallimustine selectively binds to A-T rich… 
National Institutes of Health

Related topics

Related topics

5 relations

Broader (4)

Antineoplastic AgentsAntineoplastic Agents, AlkylatingDistamycinsNitrogen Mustard Compounds

Narrower (1)

FCE 24517

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2010
2010
Birefringent physical gels of N-(4-n-alkyloxybenzoyl)-L-alanine amphiphiles in organic solvents: the role of hydrogen-bonding.
2001
2001
A new class of cytotoxic DNA minor groove binders: alpha-halogenoacrylic derivatives of pyrrolecarbamoyl oligomers.
Review
2000
Review
2000
Recent outcome in the field of distamycin-derived minor groove binders.
1999
1999
Novel benzoyl nitrogen mustard derivatives of pyrazole analogues of distamycin A: synthesis and antileukemic activity.
1999
1999
Tallimustine lesions in cellular DNA are AT sequence-specific but not region-specific.
Tallimustine (FCE 24517) is an AT-specific alkylating antitumor derivative of distamycin. This study examined levels of… 
1998
1998
A phase I and pharmacokinetic study of tallimustine [PNU 152241 (FCE 24517)] in patients with advanced cancer.
Tallimustine [PNU 152241 (FCE 24517)] is a synthetic derivative of the DNA minor groove binder distamycin A, in which the NH2… 
1998
1998
Sequence-specific DNA alkylation of novel tallimustine derivatives.
Three different groups of analogs of the sequence-specific minor groove alkylator tallimustine (2) have been synthesized and… 
1996
1996
The alkylating antitumor drug tallimustine does not induce DNA repair.
Tallimustine, an alkylating benzoyl mustard derivative of distamycin A (FCE 24517), is a novel anti-tumor agent. Both its… 
1995
1995
Comparison of cell‐cycle phase perturbations induced by the DNA‐minor‐groove alkylator tallimustine and by melphalan in the SW626 cell line
Tallimustine or N‐deformyl‐N‐[4‐N‐N,N‐bis(2‐chloroethylamino)benzoyl], a distamycin‐A derivative (FCE 24517), is a novel anti… 
1987
1987
Thermal-conductivity studies near the smectic-A-smectic-C transition in a liquid-crystal compound.
High-resolution thermal-conductivity and heat-capacity studies were carried out on the same sample in the vicinity of the smectic… 
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