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tallimustine

Known as: 1H-Pyrrole-2-carboxamide, N-(5-(((3-amino-3-iminopropyl)amino)carbonyl)-1-methyl-1H-pyrrol-3-yl)-4-(((4-((4-(bis(2-chloroethyl)amino)benzoyl)amino)-1-methyl-1H-pyrrol-2-yl)carbonyl)amino)-1-methyl-, N-deformyl-N-(4-N-N,N-bis(2-choroethylamino)benzoyl)distamycin 
A benzoyl mustard derivative of the antiviral agent distamycin A with potential antineoplastic activity. Tallimustine selectively binds to A-T rich… 
National Institutes of Health

Papers overview

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Highly Cited
2012
Highly Cited
2012
Highly Cited
2001
Highly Cited
2001
We have synthesized and evaluated a series of hybrids, denoted 22--27, for in vitro cytotoxic activity against a variety of… 
Highly Cited
2001
Highly Cited
2001
Human leukaemic K562 cells can be induced in vitro to erythroid differentiation by a variety of chemical compounds, including… 
Highly Cited
2000
Highly Cited
2000
Ecteinascidin-743 (ET-743) is a tetrahydroisoquinoline alkaloid isolated from the tunicate Ecteinascidia turbinata currently… 
Highly Cited
1995
Highly Cited
1995
FCE 24517, a novel distamycin derivative possessing potent antitumor activity, is under initial clinical investigation in Europe… 
Highly Cited
1995
Highly Cited
1995
The antibiotic distamycin A is a DNA minor groove binding drug (MGB) that recognizes a stretch of at least four ATs. The… 
1994
1994
BACKGROUND Tallimustine, a benzoyl nitrogen mustard derivative of the antiviral agent distamycin A, is a new alkylating agent… 
Highly Cited
1991
Highly Cited
1991
N-Deformyl-N-(4-N-N,N-bis(2-chloroethylamino)benzoyl)distamy cin A (FCE 24517) is a novel cytotoxic and antitumor agent shortly… 
Highly Cited
1989
Highly Cited
1989
Echinocandin B (ECB) is a lipopeptide antifungal agent produced by several species of Aspergillus. The lipid side chain of cyclic… 
1976
1976
The synthesis of a number of dialkylbenzilidene anilines is described. Mesomorphic phases are found at or below room temperature…