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tallimustine

Known as: 1H-Pyrrole-2-carboxamide, N-(5-(((3-amino-3-iminopropyl)amino)carbonyl)-1-methyl-1H-pyrrol-3-yl)-4-(((4-((4-(bis(2-chloroethyl)amino)benzoyl)amino)-1-methyl-1H-pyrrol-2-yl)carbonyl)amino)-1-methyl-, N-deformyl-N-(4-N-N,N-bis(2-choroethylamino)benzoyl)distamycin 
A benzoyl mustard derivative of the antiviral agent distamycin A with potential antineoplastic activity. Tallimustine selectively binds to A-T rich… Expand
National Institutes of Health

Papers overview

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Highly Cited
2012
Highly Cited
2012
Five water-soluble chitosan derivatives were carried out by quaternizing either iodomethane or N-(3-chloro-2-hydroxypropyl… Expand
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Highly Cited
2001
Highly Cited
2001
We have synthesized and evaluated a series of hybrids, denoted 22--27, for in vitro cytotoxic activity against a variety of… Expand
Highly Cited
2001
Highly Cited
2001
Human leukaemic K562 cells can be induced in vitro to erythroid differentiation by a variety of chemical compounds, including… Expand
Highly Cited
2000
Highly Cited
2000
Ecteinascidin-743 (ET-743) is a tetrahydroisoquinoline alkaloid isolated from the tunicate Ecteinascidia turbinata currently… Expand
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1996
1996
Tallimustine is a novel benzoyl mustard derivative from distamycin A with a unique mode of action. It is a DNA minor groove… Expand
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Highly Cited
1995
Highly Cited
1995
FCE 24517, a novel distamycin derivative possessing potent antitumor activity, is under initial clinical investigation in Europe… Expand
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Highly Cited
1995
Highly Cited
1995
The antibiotic distamycin A is a DNA minor groove binding drug (MGB) that recognizes a stretch of at least four ATs. The… Expand
1994
1994
BACKGROUND Tallimustine, a benzoyl nitrogen mustard derivative of the antiviral agent distamycin A, is a new alkylating agent… Expand
Highly Cited
1991
Highly Cited
1991
N-Deformyl-N-(4-N-N,N-bis(2-chloroethylamino)benzoyl)distamy cin A (FCE 24517) is a novel cytotoxic and antitumor agent shortly… Expand
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Highly Cited
1989
Highly Cited
1989
Echinocandin B (ECB) is a lipopeptide antifungal agent produced by several species of Aspergillus. The lipid side chain of cyclic… Expand