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tallimustine

Known as: 1H-Pyrrole-2-carboxamide, N-(5-(((3-amino-3-iminopropyl)amino)carbonyl)-1-methyl-1H-pyrrol-3-yl)-4-(((4-((4-(bis(2-chloroethyl)amino)benzoyl)amino)-1-methyl-1H-pyrrol-2-yl)carbonyl)amino)-1-methyl-, N-deformyl-N-(4-N-N,N-bis(2-choroethylamino)benzoyl)distamycin 
A benzoyl mustard derivative of the antiviral agent distamycin A with potential antineoplastic activity. Tallimustine selectively binds to A-T rich… 
National Institutes of Health

Related topics

Related topics

5 relations

Broader (4)

Antineoplastic AgentsAntineoplastic Agents, AlkylatingDistamycinsNitrogen Mustard Compounds

Narrower (1)

FCE 24517

Papers overview

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Highly Cited
2012
Highly Cited
2012
Antifungal property of quaternized chitosan and its derivatives.
2010
2010
Birefringent physical gels of N-(4-n-alkyloxybenzoyl)-L-alanine amphiphiles in organic solvents: the role of hydrogen-bonding.
Highly Cited
2001
Highly Cited
2001
Design, synthesis, DNA binding, and biological evaluation of water-soluble hybrid molecules containing two pyrazole analogues of the alkylating cyclopropylpyrroloindole (CPI) subunit of the antitumor…
We have synthesized and evaluated a series of hybrids, denoted 22--27, for in vitro cytotoxic activity against a variety of… 
Highly Cited
2001
Highly Cited
2001
Accumulation of γ‐globin mRNA and induction of erythroid differentiation after treatment of human leukaemic K562 cells with tallimustine
Human leukaemic K562 cells can be induced in vitro to erythroid differentiation by a variety of chemical compounds, including… 
1998
1998
A phase I and pharmacokinetic study of tallimustine [PNU 152241 (FCE 24517)] in patients with advanced cancer.
Tallimustine [PNU 152241 (FCE 24517)] is a synthetic derivative of the DNA minor groove binder distamycin A, in which the NH2… 
Highly Cited
1995
Highly Cited
1995
Distamycin A and tallimustine inhibit TBP binding and basal in vitro transcription.
The antibiotic distamycin A is a DNA minor groove binding drug (MGB) that recognizes a stretch of at least four ATs. The… 
1994
1994
Phase I study of the novel distamycin derivative tallimustine (FCE 24517).
BACKGROUND Tallimustine, a benzoyl nitrogen mustard derivative of the antiviral agent distamycin A, is a new alkylating agent… 
Highly Cited
1991
Highly Cited
1991
Selective DNA interaction of the novel distamycin derivative FCE 24517.
N-Deformyl-N-(4-N-N,N-bis(2-chloroethylamino)benzoyl)distamy cin A (FCE 24517) is a novel cytotoxic and antitumor agent shortly… 
Highly Cited
1989
Highly Cited
1989
Deacylation of echinocandin B by Actinoplanes utahensis.
Echinocandin B (ECB) is a lipopeptide antifungal agent produced by several species of Aspergillus. The lipid side chain of cyclic… 
1976
1976
Synthesis of Low Melting Liquid Crystalline N-(4-n-Alkylbenzilidene)-4′ -n-alkylanilines
The synthesis of a number of dialkylbenzilidene anilines is described. Mesomorphic phases are found at or below room temperature… 
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