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Nitrogen Mustard Compounds

Known as: Nitrogen Mustard Compounds [Chemical/Ingredient], Nitrogen mustards, derivative nitrogen mustard 
A group of alkylating agents derived from mustard gas, with the sulfur replaced by nitrogen. They were formerly used as toxicants and vesicants, but… 
National Institutes of Health

Related topics

Related topics

50 relations

Narrower (44)

AT 584BO-1051FONP protocolIC 140
EstramustineIn Bloodagonistsantagonists & inhibitors

Broader (1)

haloalkylamine

Papers overview

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Review
1999
Review
1999
An overview of cyclophosphamide development and clinical applications.
In this overview of the pharmacology of the anticancer drug cyclophosphamide, a brief history of the development of this drug… 
Highly Cited
1989
Highly Cited
1989
Synthesis of a duplex oligonucleotide containing a nitrogen mustard interstrand DNA-DNA cross-link.
Many cancer chemotherapeutic agents react with DNA and give adducts that block DNA replication, which is thought to result in… 
Highly Cited
1988
Highly Cited
1988
Transport, metabolism, and DNA interaction of melphalan in lymphocytes from patients with chronic lymphocytic leukemia.
We investigated the transport of [chloroethyl-14C]melphalan with lymphocytes from three groups of patients with chronic… 
Review
1988
Review
1988
Enzymatic mechanisms of resistance to alkylating agents in tumor cells and normal tissues.
Highly Cited
1970
Highly Cited
1970
Studies on possible mechanisms of programmed cell death in the chick embryo.
Highly Cited
1960
Highly Cited
1960
Studies on ultraviolet irradiation of Escherichia coli containing 5-bromouracil in its DNA.
SUMMARY: Thymine-requiring Escherichia coli 15, t– and E. coli B, t– which contained 5-bromouracil in their deoxyribonucleic acid… 
Highly Cited
1952
Highly Cited
1952
Effects of a folic acid antagonist on nucleic acid metabolism.
Highly Cited
1950
Highly Cited
1950
Chromosome Alteration and Tumour Inhibition by Nitrogen Mustards: the Hypothesis of Cross-linking Alkylation
IN the foregoing communication, attention is directed to the ability of certain monofunctional alkylating agents to produce… 
Highly Cited
1948
Highly Cited
1948
THE EFFECT OF NITROGEN MUSTARDS ON ENZYMES AND TISSUE METABOLISM
Nitrogen mustards at a concentration forty times the minimum lethal dose inhibited the respiration of all tissues studied but… 
Highly Cited
1947
Highly Cited
1947
Nitrogen mustard therapy in cutaneous blastomatous disease.
The paucity of reports in the literature on the use of nitrogen mustard therapy in cutaneous blastomatous disease leads us to… 
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