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Nitrogen Mustard Compounds

Known as: Nitrogen Mustard Compounds [Chemical/Ingredient], Nitrogen mustards, derivative nitrogen mustard 
A group of alkylating agents derived from mustard gas, with the sulfur replaced by nitrogen. They were formerly used as toxicants and vesicants, but… Expand
National Institutes of Health

Papers overview

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Review
2005
Review
2005
The era of chemotherapy began in the 1940s with the first uses of nitrogen mustards and antifolate drugs. Cancer drug development… Expand
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Review
1999
Review
1999
We include in this review an assessment of the formation, environmental fate, and mammalian and ecotoxicity of CW agent… Expand
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Review
1996
Review
1996
A number of chemotherapeutic agents, such as platinum drugs, nitrogen mustards, and chloroethylnitrosoureas, act by forming… Expand
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Review
1994
Review
1994
The nitrogen mustards are bifunctional alkylating agents which, although used extensively in cancer chemotherapy, are themselves… Expand
Highly Cited
1985
Highly Cited
1985
We have determined the effect of glutathione (GSH) depletion on the cytotoxicity of three nitrogen mustards, six platinum… Expand
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Highly Cited
1981
Highly Cited
1981
Abstract The relationship between DNA cross-linking and cell killing by cis -diamminedichloroplatinum(II) ( cis -DDP) and l… Expand
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Review
1960
Review
1960
Mustard gas [di-(2-chloroethyl) sulphide] and analogous alkylating agents produce a wide range of biological effects (cf. review… Expand
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Highly Cited
1955
Highly Cited
1955
  • R. Case, A. Lea
  • British journal of preventive & social medicine
  • 1955
  • Corpus ID: 22588452
Mustard gas (pfl-dichlor-ethyl-sulphide) and its analogues, the nitrogen mustards, are known to be carcinogenic to experimental… Expand
Review
1946
Review
1946
In a recent report the historical aspects of the use of β-chloroethyl amines (halogenated alkyl amines, nitrogen mustards) in the… Expand