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Nitrogen Mustard Compounds

Known as: Nitrogen Mustard Compounds [Chemical/Ingredient], Nitrogen mustards, derivative nitrogen mustard 
A group of alkylating agents derived from mustard gas, with the sulfur replaced by nitrogen. They were formerly used as toxicants and vesicants, but… Expand
National Institutes of Health

Papers overview

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Review
2005
Review
2005
The era of chemotherapy began in the 1940s with the first uses of nitrogen mustards and antifolate drugs. Cancer drug development… Expand
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Highly Cited
2005
Highly Cited
2005
Mammalian thioredoxin reductase (TrxR) is important for cell proliferation, antioxidant defense, and redox signaling. Together… Expand
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Review
1994
Review
1994
The nitrogen mustards are bifunctional alkylating agents which, although used extensively in cancer chemotherapy, are themselves… Expand
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1987
1987
We have reported previously (C. N. Robson et al., Cancer Res., 46: 6290-6294, 1986) the isolation of a Chinese hamster ovary cell… Expand
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Highly Cited
1986
Highly Cited
1986
Nitrogen mustards alkylate DNA primarily at the N7 position of guanine. Using an approach analogous to that of the Maxam-Gilbert… Expand
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Highly Cited
1985
Highly Cited
1985
We have determined the effect of glutathione (GSH) depletion on the cytotoxicity of three nitrogen mustards, six platinum… Expand
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Highly Cited
1985
Highly Cited
1985
A Walker 256 rat mammary carcinoma cell line (WR) resistant to bifunctional nitrogen mustards has been shown to have an… Expand
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Highly Cited
1981
Highly Cited
1981
Abstract The relationship between DNA cross-linking and cell killing by cis -diamminedichloroplatinum(II) ( cis -DDP) and l… Expand
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Highly Cited
1955
Highly Cited
1955
Mustard gas (pfl-dichlor-ethyl-sulphide) and its analogues, the nitrogen mustards, are known to be carcinogenic to experimental… Expand
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