FAQ

Nitrogen Mustard Compounds

Known as: Nitrogen Mustard Compounds [Chemical/Ingredient], Nitrogen mustards, derivative nitrogen mustard 
A group of alkylating agents derived from mustard gas, with the sulfur replaced by nitrogen. They were formerly used as toxicants and vesicants, but… (More)

Topic mentions per year

Topic mentions per year

1945-2018
010203019452017

Related topics

Related topics

50 relations

Narrower (43)

AT 584BAY-a 5850BO-1051Cloramin
(More)
EstramustineNitrogen Mustard Antineoplastic Compoundsadministration & dosageantagonists & inhibitors
(More)

Broader (1)

Mustard Compounds

Related mentions per year

Related mentions per year

1946-2018
19401960198020002020
Nitrogen Mustard Compounds
Melphalan
chemical synthesis
Estramustine
imidazole mustard
mitozolomide

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2005
Highly Cited
2005
Inhibition of thioredoxin reductase but not of glutathione reductase by the major classes of alkylating and platinum-containing anticancer compounds.
Mammalian thioredoxin reductase (TrxR) is important for cell proliferation, antioxidant defense, and redox signaling. Together… (More)
Is this relevant?
1999
1999
Measurement of drug-induced DNA interstrand crosslinking using the single-cell gel electrophoresis (comet) assay.
DNA damaging agents have been widely used in cancer chemotherapy for many years and have proved successful in the treatment of… (More)
Is this relevant?
1998
1998
DNA-Dependent protein kinase activity correlates with clinical and in vitro sensitivity of chronic lymphocytic leukemia lymphocytes to nitrogen mustards.
The objective of this study is to investigate the role of DNA-dependent protein kinase (DNA-PK) in the chronic lymphocytic… (More)
  • table 1
  • figure 2
  • figure 1
  • table 2
  • figure 3
Is this relevant?
1998
1998
Potentiation of chlorambucil cytotoxicity in B-cell chronic lymphocytic leukemia by inhibition of DNA-dependent protein kinase activity using wortmannin.
In this study, we examined the ability of wortmannin to modulate chlorambucil (CLB) cytotoxicity in lymphocyte samples from… (More)
  • figure 1
  • table 1
  • table 2
Is this relevant?
1991
1991
Increased DNA synthesis and repair-enzyme expression in lymphocytes from patients with chronic lymphocytic leukemia resistant to nitrogen mustards.
Resistance to the nitrogen mustards in patients with chronic lymphocytic leukemia (CLL) correlates with an enhanced removal of… (More)
Is this relevant?
Highly Cited
1988
Highly Cited
1988
Ethacrynic acid and piriprost as enhancers of cytotoxicity in drug resistant and sensitive cell lines.
Ethacrynic acid and piriprost (6,9-deepoxy-6,9-(phenylimino)-delta 6,8-prostaglandin I1) have been shown to potentiate the… (More)
  • figure 4
  • figure 2
  • table 2
  • table 3
Is this relevant?
1987
1987
Mechanisms of DNA sequence selective alkylation of guanine-N7 positions by nitrogen mustards.
Quantitative determinations were carried out of the relative reaction rates of several nitrogen mustards at various guanine-N7… (More)
  • figure 1
  • table 1
  • figure 2
  • table 2
  • figure 3
Is this relevant?
1986
1986
DNA sequence selectivity of guanine-N7 alkylation by nitrogen mustards.
Nitrogen mustards alkylate DNA primarily at the N7 position of guanine. Using an approach analogous to that of the Maxam-Gilbert… (More)
  • figure 1
  • figure 3
  • table 1
  • figure 7
Is this relevant?
Highly Cited
1985
Highly Cited
1985
Increased glutathione-S-transferase activity in a cell line with acquired resistance to nitrogen mustards.
A Walker 256 rat mammary carcinoma cell line (WR) resistant to bifunctional nitrogen mustards has been shown to have an… (More)
Is this relevant?
Highly Cited
1985
Highly Cited
1985
Differential potentiation of alkylating and platinating agent cytotoxicity in human ovarian carcinoma cells by glutathione depletion.
We have determined the effect of glutathione (GSH) depletion on the cytotoxicity of three nitrogen mustards, six platinum… (More)
  • table 2
  • table 1
Is this relevant?