Nitrogen Mustard Compounds
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The era of chemotherapy began in the 1940s with the first uses of nitrogen mustards and antifolate drugs. Cancer drug development… Expand We include in this review an assessment of the formation, environmental fate, and mammalian and ecotoxicity of CW agent… Expand A number of chemotherapeutic agents, such as platinum drugs, nitrogen mustards, and chloroethylnitrosoureas, act by forming… Expand The nitrogen mustards are bifunctional alkylating agents which, although used extensively in cancer chemotherapy, are themselves… Expand We have determined the effect of glutathione (GSH) depletion on the cytotoxicity of three nitrogen mustards, six platinum… Expand Abstract The relationship between DNA cross-linking and cell killing by cis -diamminedichloroplatinum(II) ( cis -DDP) and l… Expand Mustard gas [di-(2-chloroethyl) sulphide] and analogous alkylating agents produce a wide range of biological effects (cf. review… Expand Mustard gas (pfl-dichlor-ethyl-sulphide) and its analogues, the nitrogen mustards, are known to be carcinogenic to experimental… Expand In a recent report the historical aspects of the use of β-chloroethyl amines (halogenated alkyl amines, nitrogen mustards) in the… Expand