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Nitrogen Mustard Compounds

Known as: Nitrogen Mustard Compounds [Chemical/Ingredient], Nitrogen mustards, derivative nitrogen mustard 
A group of alkylating agents derived from mustard gas, with the sulfur replaced by nitrogen. They were formerly used as toxicants and vesicants, but… Expand
National Institutes of Health

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Narrower (44)

AT 584BO-1051FONP protocolIC 140
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EstramustineIn Bloodagonistsantagonists & inhibitors
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Broader (1)

haloalkylamine

Papers overview

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Review
2005
Review
2005
Chemotherapy and the war on cancer
The era of chemotherapy began in the 1940s with the first uses of nitrogen mustards and antifolate drugs. Cancer drug development… Expand
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Highly Cited
2005
Highly Cited
2005
Inhibition of thioredoxin reductase but not of glutathione reductase by the major classes of alkylating and platinum-containing anticancer compounds.
Mammalian thioredoxin reductase (TrxR) is important for cell proliferation, antioxidant defense, and redox signaling. Together… Expand
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Review
1994
Review
1994
DNA damage and mutagenesis induced by nitrogen mustards.
The nitrogen mustards are bifunctional alkylating agents which, although used extensively in cancer chemotherapy, are themselves… Expand
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1987
1987
Reduced levels of drug-induced DNA cross-linking in nitrogen mustard-resistant Chinese hamster ovary cells expressing elevated glutathione S-transferase activity.
We have reported previously (C. N. Robson et al., Cancer Res., 46: 6290-6294, 1986) the isolation of a Chinese hamster ovary cell… Expand
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Highly Cited
1986
Highly Cited
1986
DNA sequence selectivity of guanine-N7 alkylation by nitrogen mustards.
Nitrogen mustards alkylate DNA primarily at the N7 position of guanine. Using an approach analogous to that of the Maxam-Gilbert… Expand
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Highly Cited
1985
Highly Cited
1985
Differential potentiation of alkylating and platinating agent cytotoxicity in human ovarian carcinoma cells by glutathione depletion.
We have determined the effect of glutathione (GSH) depletion on the cytotoxicity of three nitrogen mustards, six platinum… Expand
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Highly Cited
1985
Highly Cited
1985
Increased glutathione-S-transferase activity in a cell line with acquired resistance to nitrogen mustards.
A Walker 256 rat mammary carcinoma cell line (WR) resistant to bifunctional nitrogen mustards has been shown to have an… Expand
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Highly Cited
1981
Highly Cited
1981
DNA cross-linking as an indicator of sensitivity and resistance of mouse L1210 leukemia to cis-diamminedichloroplatinum(II) and L-phenylalanine mustard.
Abstract The relationship between DNA cross-linking and cell killing by cis -diamminedichloroplatinum(II) ( cis -DDP) and l… Expand
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Highly Cited
1955
Highly Cited
1955
Mustard gas poisoning, chronic bronchitis, and lung cancer; an investigation into the possibility that poisoning by mustard gas in the 1914-18 war might be a factor in the production of neoplasia.
Mustard gas (pfl-dichlor-ethyl-sulphide) and its analogues, the nitrogen mustards, are known to be carcinogenic to experimental… Expand
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Highly Cited
1948
Highly Cited
1948
The use of the nitrogen mustards in the palliative treatment of carcinoma. With particular reference to bronchogenic carcinoma
 
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