Nitrogen Mustard Compounds

Known as: Nitrogen Mustard Compounds [Chemical/Ingredient], Nitrogen mustards, derivative nitrogen mustard 
A group of alkylating agents derived from mustard gas, with the sulfur replaced by nitrogen. They were formerly used as toxicants and vesicants, but… (More)

Topic mentions per year

Topic mentions per year

1945-2018
010203019452017

Papers overview

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Highly Cited
2005
Highly Cited
2005
Mammalian thioredoxin reductase (TrxR) is important for cell proliferation, antioxidant defense, and redox signaling. Together… (More)
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1999
1999
DNA damaging agents have been widely used in cancer chemotherapy for many years and have proved successful in the treatment of… (More)
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1998
1998
The objective of this study is to investigate the role of DNA-dependent protein kinase (DNA-PK) in the chronic lymphocytic… (More)
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1998
1998
In this study, we examined the ability of wortmannin to modulate chlorambucil (CLB) cytotoxicity in lymphocyte samples from… (More)
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1991
1991
Resistance to the nitrogen mustards in patients with chronic lymphocytic leukemia (CLL) correlates with an enhanced removal of… (More)
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Highly Cited
1988
Highly Cited
1988
Ethacrynic acid and piriprost (6,9-deepoxy-6,9-(phenylimino)-delta 6,8-prostaglandin I1) have been shown to potentiate the… (More)
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1987
1987
Quantitative determinations were carried out of the relative reaction rates of several nitrogen mustards at various guanine-N7… (More)
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1986
1986
Nitrogen mustards alkylate DNA primarily at the N7 position of guanine. Using an approach analogous to that of the Maxam-Gilbert… (More)
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Highly Cited
1985
Highly Cited
1985
A Walker 256 rat mammary carcinoma cell line (WR) resistant to bifunctional nitrogen mustards has been shown to have an… (More)
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Highly Cited
1985
Highly Cited
1985
We have determined the effect of glutathione (GSH) depletion on the cytotoxicity of three nitrogen mustards, six platinum… (More)
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