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Nitrogen Mustard Compounds

Known as: Nitrogen Mustard Compounds [Chemical/Ingredient], Nitrogen mustards, derivative nitrogen mustard 
A group of alkylating agents derived from mustard gas, with the sulfur replaced by nitrogen. They were formerly used as toxicants and vesicants, but… 
National Institutes of Health

Related topics

Related topics

50 relations

Narrower (44)

AT 584BO-1051FONP protocolIC 140
EstramustineIn Bloodagonistsantagonists & inhibitors

Broader (1)

haloalkylamine

Papers overview

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Review
2005
Review
2005
Chemotherapy and the war on cancer
The era of chemotherapy began in the 1940s with the first uses of nitrogen mustards and antifolate drugs. Cancer drug development… 
Highly Cited
2005
Highly Cited
2005
Inhibition of thioredoxin reductase but not of glutathione reductase by the major classes of alkylating and platinum-containing anticancer compounds.
Review
1999
Review
1999
The sources, fate, and toxicity of chemical warfare agent degradation products.
We include in this review an assessment of the formation, environmental fate, and mammalian and ecotoxicity of CW agent… 
Review
1996
Review
1996
DNA repair: enzymatic mechanisms and relevance to drug response.
A number of chemotherapeutic agents, such as platinum drugs, nitrogen mustards, and chloroethylnitrosoureas, act by forming… 
Review
1994
Review
1994
DNA damage and mutagenesis induced by nitrogen mustards.
Highly Cited
1985
Highly Cited
1985
Differential potentiation of alkylating and platinating agent cytotoxicity in human ovarian carcinoma cells by glutathione depletion.
We have determined the effect of glutathione (GSH) depletion on the cytotoxicity of three nitrogen mustards, six platinum… 
Highly Cited
1981
Highly Cited
1981
DNA cross-linking as an indicator of sensitivity and resistance of mouse L1210 leukemia to cis-diamminedichloroplatinum(II) and L-phenylalanine mustard.
Abstract The relationship between DNA cross-linking and cell killing by cis -diamminedichloroplatinum(II) ( cis -DDP) and l… 
Review
1960
Review
1960
The reaction of mustard gas with nucleic acids in vitro and in vivo.
Mustard gas [di-(2-chloroethyl) sulphide] and analogous alkylating agents produce a wide range of biological effects (cf. review… 
Highly Cited
1948
Highly Cited
1948
The use of the nitrogen mustards in the palliative treatment of carcinoma. With particular reference to bronchogenic carcinoma
Review
1946
Review
1946
Nitrogen mustard therapy; use of methyl-bis (beta-chloroethyl) amine hydrochloride and tris (beta-chloroethyl) amine hydrochloride for Hodgkin's disease, lymphosarcoma, leukemia and certain allied…
In a recent report the historical aspects of the use of β-chloroethyl amines (halogenated alkyl amines, nitrogen mustards) in the… 
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