The reaction of mustard gas with nucleic acids in vitro and in vivo.


Mustard gas [di-(2-chloroethyl) sulphide] and analogous alkylating agents produce a wide range of biological effects (cf. review by Boyland, 1948). Some ofthese effects, such as induction ofmutations (Auerbach & Robson, 1946) and interference with mitosis and chromosome breakage (Darlington & Koller, 1947), stimulated interest in the reactions of alkylating… (More)


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