FAQ

Estramustine

Known as: EM, 17beta-(estra-1,3,5(10)-triene-3,17-diol 3-(bis(2-chloroethyl)carbamate)), Estra-1,3,5(10)-triene-3,17-diol (17beta)-, 3-(bis(2-chloroethyl)carbamate) 
A synthetic molecule combining estradiol and nornitrogen mustard through a carbamate link. Estramustine and its major metabolite estramustine bind to… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1959-2018
05010019592018

Related topics

Related topics

20 relations

Broader (1)

Antineoplastic Agents, Alkylating
Drug AllergyEstradiolIn BloodNitrogen Mustard Compounds
(More)

Narrower (5)

EmcytEstracytEstramustine Phosphate SodiumEstramustine phosphate
(More)

Related mentions per year

Related mentions per year

1936-2018
19401960198020002020
Estramustine
Drug Allergy
Prostatic Neoplasms
Estradiol
agonists
Thromboembolism

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2012
Highly Cited
2012
CYP2D6 genotype and tamoxifen response in postmenopausal women with endocrine-responsive breast cancer: the breast international group 1-98 trial.
BACKGROUND Adjuvant tamoxifen therapy is effective for postmenopausal women with endocrine-responsive breast cancer. Cytochrome… (More)
  • figure 1
  • table 1
  • table 2
  • figure 2
  • figure 3
Is this relevant?
Highly Cited
2012
Highly Cited
2012
CYP2D6 and UGT2B7 genotype and risk of recurrence in tamoxifen-treated breast cancer patients.
BACKGROUND Adjuvant tamoxifen therapy substantially decreases the risk of recurrence and mortality in women with hormone… (More)
Is this relevant?
Highly Cited
2009
Highly Cited
2009
Thrombus aspiration during primary percutaneous coronary intervention improves myocardial reperfusion and reduces infarct size: the EXPIRA (thrombectomy with export catheter in infarct-related artery…
OBJECTIVES The purpose of this study was to evaluate the impact on myocardial perfusion and infarct size as assessed by contrast… (More)
  • figure 1
  • table 1
  • table 2
  • table 3
  • figure 2
Is this relevant?
Highly Cited
2004
Highly Cited
2004
Docetaxel and estramustine compared with mitoxantrone and prednisone for advanced refractory prostate cancer.
BACKGROUND Mitoxantrone-based chemotherapy palliates pain without extending survival in men with progressive androgen-independent… (More)
Is this relevant?
Highly Cited
2001
Highly Cited
2001
Periaqueductal gray matter dysfunction in migraine: cause or the burden of illness?
OBJECTIVE The periaqueductal gray matter (PAG) is at the center of a powerful descending antinociceptive neuronal network. We… (More)
Is this relevant?
Highly Cited
2000
Highly Cited
2000
Non-verbal semantic impairment in semantic dementia.
The clinical presentation of patients with semantic dementia is dominated by anomia and poor verbal comprehension. Although a… (More)
  • table 1
  • table 2
  • figure 1
  • figure 2
Is this relevant?
Highly Cited
1998
Highly Cited
1998
Improvement of survival in patients with diffuse panbronchiolitis treated with low-dose erythromycin.
Diffuse panbronchiolitis (DPB) is a chronic inflammatory disease of the airways with a high rate of mortality despite treatment… (More)
Is this relevant?
Highly Cited
1997
Highly Cited
1997
A Synthetic Peptide Corresponding to the Extracellular Domain of Occludin Perturbs the Tight Junction Permeability Barrier
Occludin, the putative tight junction integral membrane protein, is an attractive candidate for a protein that forms the actual… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
Highly Cited
1993
Highly Cited
1993
Actin microfilaments play a critical role in endocytosis at the apical but not the basolateral surface of polarized epithelial cells
Treatment with cytochalasin D, a drug that acts by inducing the depolymerization of the actin cytoskeleton, selectively blocked… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
1993
1993
Estramustine depolymerizes microtubules by binding to tubulin.
To investigate the mechanism of action of the antineoplastic drug estramustine, we compared its effects on human prostate cancer… (More)
Is this relevant?