Estramustine

Known as: EM, 17beta-(estra-1,3,5(10)-triene-3,17-diol 3-(bis(2-chloroethyl)carbamate)), Estra-1,3,5(10)-triene-3,17-diol (17beta)-, 3-(bis(2-chloroethyl)carbamate) 
A synthetic molecule combining estradiol and nornitrogen mustard through a carbamate link. Estramustine and its major metabolite estramustine bind to… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1959-2018
05010019592018

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Highly Cited
2012
Highly Cited
2012
BACKGROUND Adjuvant tamoxifen therapy is effective for postmenopausal women with endocrine-responsive breast cancer. Cytochrome… (More)
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Highly Cited
2012
Highly Cited
2012
BACKGROUND Adjuvant tamoxifen therapy substantially decreases the risk of recurrence and mortality in women with hormone… (More)
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Highly Cited
2009
Highly Cited
2009
OBJECTIVES The purpose of this study was to evaluate the impact on myocardial perfusion and infarct size as assessed by contrast… (More)
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Highly Cited
2004
Highly Cited
2004
BACKGROUND Mitoxantrone-based chemotherapy palliates pain without extending survival in men with progressive androgen-independent… (More)
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Highly Cited
2001
Highly Cited
2001
OBJECTIVE The periaqueductal gray matter (PAG) is at the center of a powerful descending antinociceptive neuronal network. We… (More)
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Highly Cited
2000
Highly Cited
2000
The clinical presentation of patients with semantic dementia is dominated by anomia and poor verbal comprehension. Although a… (More)
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Highly Cited
1998
Highly Cited
1998
Diffuse panbronchiolitis (DPB) is a chronic inflammatory disease of the airways with a high rate of mortality despite treatment… (More)
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Highly Cited
1997
Highly Cited
1997
Occludin, the putative tight junction integral membrane protein, is an attractive candidate for a protein that forms the actual… (More)
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Highly Cited
1993
Highly Cited
1993
Treatment with cytochalasin D, a drug that acts by inducing the depolymerization of the actin cytoskeleton, selectively blocked… (More)
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1993
1993
To investigate the mechanism of action of the antineoplastic drug estramustine, we compared its effects on human prostate cancer… (More)
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