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Estramustine Phosphate Sodium

Known as: Phosphate Sodium, Estramustine, estra-1,3,5(10)-triene-3,17-diol(17(beta))-, 3-[bis(2-chloroethyl)carbamate] 17-(dihydrogen phosphate), disodium salt, monohydrate, Estramustine Sodium Phosphate 
The orally available disodium salt, monohydrate, of estramustine phosphate, a synthetic molecule that combines estradiol and nornitrogen mustard… Expand
National Institutes of Health

Related topics

Related topics

14 relations
Alkylating Activity [MoA]Drug AllergyEstradiolEstramustine phosphate
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Narrower (2)

EmcytEstracyt

Broader (1)

Estramustine

Papers overview

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2002
2002
An active regimen of weekly paclitaxel and estramustine in metastatic androgen-independent prostate cancer.
OBJECTIVES The efficacy of weekly high-dose paclitaxel in androgen-independent prostate carcinoma and its cytotoxic synergy with… Expand
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Review
2001
Review
2001
Necessity of re-evaluation of estramustine phosphate sodium (EMP) as a treatment option for first-line monotherapy in advanced prostate cancer.
  • Tadaichi Kitamura
  • International journal of urology : official…
  • 2001
    • Corpus ID: 43384150
Estramustine phosphate sodium (EMP) was first introduced in the early 1970s for the treatment of prostate cancer, when EMP was… Expand
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1998
1998
Amplification of the ATP-binding cassette 2 transporter gene is functionally linked with enhanced efflux of estramustine in ovarian carcinoma cells.
An estramustine-resistant human ovarian carcinoma cell line, SKEM, was generated to explore resistance mechanisms associated with… Expand
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Highly Cited
1996
Highly Cited
1996
Treatment of hormone-refractory prostate cancer with 90Y-CYT-356 monoclonal antibody.
A Phase I dose-escalation study using 90Y-CYT-356 monoclonal antibody was performed in 12 patients with hormone-refractory… Expand
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Review
1995
Review
1995
Estramustine Phosphate Sodium
SummarySynopsisEstramustine phosphate sodium (estramustine phosphate), a unique antitumour agent, is selectively taken up by… Expand
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1992
1992
Evidence for a non-estrogenic cytostatic effect of estramustine on human prostatic carcinoma cells in vivo.
Estramustine is one of the main metabolites of estramustine phosphate (EstracytR), a drug used in the treatment of advanced… Expand
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1991
1991
The effect of estramustine derivatives on microtubule assembly in vitro depends on the charge of the substituent.
Estramustine, and derivatives of estramustine with a charged substituent at position 17 on the estrogen moiety, have been… Expand
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1988
1988
Estramustine binds MAP-2 to inhibit microtubule assembly in vitro.
We have investigated the ability of estramustine to bind to rat brain microtubule-associated proteins (MAPs) and purified MAP-2… Expand
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1985
1985
Dansylated estramustine, a fluorescent probe for studies of estramustine uptake and identification of intracellular targets.
Fluorescence-microscopic studies with dansylated estramustine (DnsEM) has permitted investigation of the mechanism of… Expand
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Review
1984
Review
1984
Estramustine Phosphate Sodium
Estramustine phosphate is approved by the Food and Drug Administration for oral use in the palliative treatment of patients with… Expand
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