• Publications
  • Influence
Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy
BRCA1 and BRCA2 are important for DNA double-strand break repair by homologous recombination, and mutations in these genes predispose to breast and other cancers. Poly(ADP-ribose) polymerase (PARP)Expand
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The Bloom's syndrome helicase suppresses crossing over during homologous recombination
Mutations in BLM, which encodes a RecQ helicase, give rise to Bloom's syndrome, a disorder associated with cancer predisposition and genomic instability. A defining feature of Bloom's syndrome is anExpand
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Replication stress induces sister-chromatid bridging at fragile site loci in mitosis
Several inherited syndromes in humans are associated with cancer predisposition. The gene products defective in two of these disorders, BLM (a helicase defective in Bloom's syndrome) and FANC A–NExpand
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XRCC1 coordinates the initial and late stages of DNA abasic site repair through protein–protein interactions
The major human AP endonuclease APE1 (HAP1, APEX, Ref1) initiates the repair of abasic sites generated either spontaneously, from attack of bases by free radicals, or during the course of the repairExpand
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BLM is required for faithful chromosome segregation and its localization defines a class of ultrafine anaphase bridges
Mutations in BLM cause Bloom's syndrome, a disorder associated with cancer predisposition and chromosomal instability. We investigated whether BLM plays a role in ensuring the faithful chromosomeExpand
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53BP1 nuclear bodies form around DNA lesions generated by mitotic transmission of chromosomes under replication stress
Completion of genome duplication is challenged by structural and topological barriers that impede progression of replication forks. Although this can seriously undermine genome integrity, the fate ofExpand
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RecQ helicases: caretakers of the genome
  • I. Hickson
  • Biology, Medicine
  • Nature Reviews Cancer
  • 1 March 2003
RecQ helicases are highly conserved from bacteria to man. Germline mutations in three of the five known family members in humans give rise to debilitating disorders that are characterized by, amongstExpand
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The structure-specific endonuclease Mus81 contributes to replication restart by generating double-strand DNA breaks
Faithful duplication of the genome requires structure-specific endonucleases such as the RuvABC complex in Escherichia coli. These enzymes help to resolve problems at replication forks that have beenExpand
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Replication stress activates DNA repair synthesis in mitosis
Oncogene-induced DNA replication stress has been implicated as a driver of tumorigenesis. Many chromosomal rearrangements characteristic of human cancers originate from specific regions of the genomeExpand
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The Bloom’s Syndrome Helicase Unwinds G4 DNA*
BLM, the gene that is defective in Bloom’s syndrome, encodes a protein homologous to RecQ subfamily helicases that functions as a 3′-5′ DNA helicase in vitro. We now report that the BLM helicase canExpand
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