FCE 24517

Known as: FCE-24517 
 
National Institutes of Health

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tallimustine

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1999
1999
FCE 24517-resistant MCF-7 human breast cancer cell line: selection and characterization.
We have developed a stable line of the human breast carcinoma cell line MCF-7 by in vitro continuous exposure to increasing… (More)
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1998
1998
A phase I and pharmacokinetic study of tallimustine [PNU 152241 (FCE 24517)] in patients with advanced cancer.
Tallimustine [PNU 152241 (FCE 24517)] is a synthetic derivative of the DNA minor groove binder distamycin A, in which the NH2… (More)
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1996
1996
Backbone and benzoyl mustard carrying moiety modifies DNA interactions of distamycin analogues.
Alkylating distamycin derivative FCE-24517 (l) is the prototype of a novel class of alkylating agents. In the present study we… (More)
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1994
1994
3T3 NIH murine fibroblasts and B78 murine melanoma cells expressing the Escherichia coli N3-methyladenine-DNA glycosylase I do not become resistant to alkylating agents.
The role of alkylation of the N3 position of adenine in the cytotoxicity of alkylating agents in mammalian cells is still… (More)
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1993
1993
Characterisation of a LoVo subline resistant to a benzoyl mustard derivative of distamycin A (FCE 24517).
Human colon adenocarcinoma cells (LoVo) resistant to the new antitumor agent FCE 24517 [benzoyl-mustard derivative of distamycin… (More)
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1993
1993
Intracellular glutathione heterogeneity in L1210 murine leukemia sublines made resistant to DNA-interacting anti-neoplastic agents.
Intracellular glutathione (GSH) content was measured by flow cytometry using monochlorobimane (mBCl) and by the enzymatic assay… (More)
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1993
1993
The effects of a benzoic acid mustard derivative of distamycin A (FCE 24517) and related minor groove-binding distamycin analogues on the activity of major groove-binding alkylating agents.
The distamycin derivative FCE 24517 is a potent antitumour agent. Efforts have been made towards elucidating the mechanism of… (More)
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1992
1992
The unique interaction with immunity of FCE 24517, an antitumor drug with a novel mode of action.
The present study was designed to characterize in mice the effects on the immune system of the antineoplastic agent FCE 24517, a… (More)
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1991
1991
Selective DNA interaction of the novel distamycin derivative FCE 24517.
N-Deformyl-N-(4-N-N,N-bis(2-chloroethylamino)benzoyl)distamy cin A (FCE 24517) is a novel cytotoxic and antitumor agent shortly… (More)
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1991
1991
Biological profile of FCE 24517, a novel benzoyl mustard analogue of distamycin A.
FCE 24157 (chemically (beta-[1-methyl-4-(1-methyl-4--[1-methyl-4-(4-N,N- bis(2-chloroethyl) amino-benzene-1-carboxy-amido… (More)
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