FCE 24517

We have developed a stable line of the human breast carcinoma cell line MCF-7 by in vitro continuous exposure to increasing… Expand

Tallimustine [PNU 152241 (FCE 24517)] is a synthetic derivative of the DNA minor groove binder distamycin A, in which the NH2… Expand

Alkylating distamycin derivative FCE-24517 (l) is the prototype of a novel class of alkylating agents. In the present study we… Expand

The role of alkylation of the N3 position of adenine in the cytotoxicity of alkylating agents in mammalian cells is still… Expand

Human colon adenocarcinoma cells (LoVo) resistant to the new antitumor agent FCE 24517 [benzoyl-mustard derivative of distamycin… Expand

The distamycin derivative FCE 24517 is a potent antitumour agent. Efforts have been made towards elucidating the mechanism of… Expand

Intracellular glutathione (GSH) content was measured by flow cytometry using monochlorobimane (mBCI) and by the enzymatic assay… Expand

The present study was designed to characterize in mice the effects on the immune system of the antineoplastic agent FCE 24517, a… Expand

N-Deformyl-N-(4-N-N,N-bis(2-chloroethylamino)benzoyl)distamy cin A (FCE 24517) is a novel cytotoxic and antitumor agent shortly… Expand

FCE 24157 (chemically (beta-[1-methyl-4-(1-methyl-4--[1-methyl-4-(4-N,N- bis(2-chloroethyl) amino-benzene-1-carboxy-amido… Expand