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Distamycins

Known as: Distamycin Antineoplastic Antibiotic, Distamycins [Chemical/Ingredient] 
An antineoplastic antibiotic isolated from the bacterium Streptomyces distallicus. Distamycin antibiotics bind to the minor groove of DNA… 
National Institutes of Health

Related topics

Related topics

29 relations

Narrower (21)

2-imidazoledistamycinDistelFCE 24561FCE 25450A

Broader (2)

Anti-Bacterial AgentsNucleic Acid Synthesis Inhibitors
In Bloodagonistsantagonists & inhibitorsaspects of radiation effects

Papers overview

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Review
2010
Review
2010
Distamycins: strategies for possible enhancement of activity and specificity.
The present review focused on the strategies aimed to possibly solve toxicity problems of distamycins. Distamycins are compounds… 
2004
2004
Liposomes Containing Distamycins: Preparation, Characterization and Antiproliferative Activity
This article describes the production and characterization of two liposome formulations containing antitumor drugs, namely… 
Review
1999
Review
1999
DNA minor-groove binders: results and design of new antitumor agents.
1997
1997
Non-covalent complexes between DNA-binding drugs and double-stranded deoxyoligonucleotides: a study by ionspray mass spectrometry.
The non-covalent complexes between some DNA-binding drugs and duplex oligodeoxynucleotides were studied by ionspray mass… 
1996
1996
Distamycin A complexation with a nucleic acid triple helix.
The interaction of the minor groove binding drug distamycin with the T-A-T triple helix and the A-T double helix was studied… 
Review
1991
Review
1991
Management of AIDS and its neoplastic complications.
1991
1991
Inhibition of human DNA ligase by anthracyclines and distamycins.
Antitumor anthracyclines and distamycins behave as strong inhibitors of human replicative DNA ligase. The enzyme appears… 
1982
1982
Specific interaction of netropsin, distamycin-3 and analogs with LC duplexes: reversion towards the B form of the 2'-deoxy-.2'-deoxy-2'-fluoro-hybrid duplexes upon specific interaction with netropsin…
Binding of the B-form specific ligands netropsin and distamycin-3, -4 and -5 has been used to monitor the presence and/or the… 
Highly Cited
1977
Highly Cited
1977
Specific interactions of distamycin A and its analogs with (A-T) rich and (G-C) rich duplex regions of DNA and deoxypolynucleotides.
The specific interaction of distamycin A and analogs with DNA's and synthetic deoxypolynucleotide duplexes were studied in detail… 
1971
1971
Some structural requirements for the antibiotic action of distamycins
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