Skip to search formSkip to main contentSkip to account menu

sulforafan

Known as: sulforaphane, (R)-, 1-isothiocyanato-4-methylsulfinyl-butane, 1-isothiocyanato-4-methylsulphinylbutane 
A naturally-occurring phytochemical belonging to the class of isothiocyanates. As the aglycone metabolite of glucosinolate glucoraphanin… 
National Institutes of Health

Related topics

Related topics

2 relations

Broader (2)

Anticarcinogenic AgentsIsothiocyanates

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2010
Review
2010
Regulation of survival, proliferation, invasion, angiogenesis, and metastasis of tumor cells through modulation of inflammatory pathways by nutraceuticals
Almost 25 centuries ago, Hippocrates, the father of medicine, proclaimed “Let food be thy medicine and medicine be thy food… 
Review
2010
Review
2010
Molecular Targets of Dietary Phenethyl Isothiocyanate and Sulforaphane for Cancer Chemoprevention
Development of cancer is a long-term and multistep process which comprises initiation, progression, and promotion stages of… 
Highly Cited
2006
Highly Cited
2006
Mechanism of action of sulforaphane: inhibition of p38 mitogen-activated protein kinase isoforms contributing to the induction of antioxidant response element-mediated heme oxygenase-1 in human…
Exposure of sulforaphane to HepG2 cells increased heme oxygenase-1 (HO-1) expression by activating antioxidant response element… 
Highly Cited
2005
Highly Cited
2005
Reversal of Hypermethylation and Reactivation of p16INK4a, RARβ, and MGMT Genes by Genistein and Other Isoflavones from Soy
Purpose: We have previously shown the reactivation of some methylation-silenced genes in cancer cells by (−)-epigallocatechin-3… 
Highly Cited
2004
Highly Cited
2004
Sulforaphane-induced G2/M Phase Cell Cycle Arrest Involves Checkpoint Kinase 2-mediated Phosphorylation of Cell Division Cycle 25C*
Previously, we showed that sulforaphane (SFN), a naturally occurring cancer chemopreventive agent, effectively inhibits… 
Highly Cited
2003
Highly Cited
2003
Sulforaphane induces caspase-mediated apoptosis in cultured PC-3 human prostate cancer cells and retards growth of PC-3 xenografts in vivo.
Sulforaphane (SFN), a constituent of cruciferous vegetables, is highly effective in affording protection against chemically… 
Review
2002
Review
2002
Pharmacogenomics, regulation and signaling pathways of phase I and II drug metabolizing enzymes.
Drug or xenobiotics metabolizing enzymes (DMEs or XMEs) play central roles in the biotransformation, metabolism and/or… 
Highly Cited
2000
Highly Cited
2000
Sulforaphane, a naturally occurring isothiocyanate, induces cell cycle arrest and apoptosis in HT29 human colon cancer cells.
Sulforaphane is an isothiocyanate that is present naturally in widely consumed vegetables and has a particularly high… 
Highly Cited
2000
Highly Cited
2000
Chemoprevention of colonic aberrant crypt foci in Fischer rats by sulforaphane and phenethyl isothiocyanate.
Epidemiological studies have linked consumption of broccoli to a reduced risk of colon cancer in individuals with the glutathione… 
Review
1999
Review
1999
Chemoprevention of cancer by isothiocyanates, modifiers of carcinogen metabolism.
Substantial quantities of isothiocyanates are released upon consumption of normal amounts of a number of cruciferous vegetables… 
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy (opens in a new tab), Terms of Service (opens in a new tab), and Dataset License (opens in a new tab)