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sulforafan

Known as: sulforaphane, (R)-, 1-isothiocyanato-4-methylsulfinyl-butane, 1-isothiocyanato-4-methylsulphinylbutane 
A naturally-occurring phytochemical belonging to the class of isothiocyanates. As the aglycone metabolite of glucosinolate glucoraphanin… 
National Institutes of Health

Related topics

Related topics

2 relations

Broader (2)

Anticarcinogenic AgentsIsothiocyanates

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2012
Highly Cited
2012
Biotransformation of the Antiretroviral Drug Etravirine: Metabolite Identification, Reaction Phenotyping, and Characterization of Autoinduction of Cytochrome P450-Dependent Metabolism
Etravirine (ETR) is a second-generation non-nucleoside reverse transcriptase inhibitor prescribed for the treatment of HIV-1. By… 
Review
2010
Review
2010
Mouse models for unraveling the importance of diet in colon cancer prevention.
Highly Cited
2008
Highly Cited
2008
Computational Discovery of Novel Low Micromolar Human Pregnane X Receptor Antagonists
Very few antagonists have been identified for the human pregnane X receptor (PXR). These molecules may be of use for modulating… 
Highly Cited
2008
Highly Cited
2008
Quantification of sulforaphane mercapturic acid pathway conjugates in human urine by high-performance liquid chromatography and isotope-dilution tandem mass spectrometry.
We report validation of the first high-pressure liquid chromatography isotope-dilution mass spectrometry method to measure… 
Highly Cited
2006
Highly Cited
2006
Potent activation of mitochondria-mediated apoptosis and arrest in S and M phases of cancer cells by a broccoli sprout extract
We have previously shown that broccoli sprouts are a rich source of chemopreventive isothiocyanates, which potently induce… 
Highly Cited
2006
Highly Cited
2006
Sulforaphane sensitizes tumor necrosis factor-related apoptosis-inducing ligand-mediated apoptosis through downregulation of ERK and Akt in lung adenocarcinoma A549 cells.
The cytotoxic effect of the tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is limited in some cancer cells… 
Highly Cited
2004
Highly Cited
2004
Induction of medulloblastoma cell apoptosis by sulforaphane, a dietary anticarcinogen from Brassica vegetables.
Highly Cited
2003
Highly Cited
2003
Sulforaphane and quercetin modulate PhIP-DNA adduct formation in human HepG2 cells and hepatocytes.
The formation of DNA adducts in human HepG2 cells and human hepatocytes exposed to 14C-labelled 2-amino-1-methyl-6-phenylimidazo… 
Highly Cited
2003
Highly Cited
2003
Synergy between sulforaphane and selenium in the induction of thioredoxin reductase 1 requires both transcriptional and translational modulation.
Thioredoxin reductases (TrxRs) catalyse the NADPH-dependent reduction of thioredoxin and play an important role in multiple… 
Highly Cited
2003
Highly Cited
2003
Differential responses from seven mammalian cell lines to the treatments of detoxifying enzyme inducers.
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